Molecular Formula | C36H33ClN2O7 |
Molar Mass | 641.11 |
Density | 1.42±0.1 g/cm3(Predicted) |
Boling Point | 817.5±65.0 °C(Predicted) |
Solubility | DMSO : 125 mg/mL (194.97 mM; Need ultrasonic) |
pKa | 2.03±0.40(Predicted) |
Storage Condition | -20°C |
Physical and Chemical Properties | Bioactive BMS-1166 is a new and effective inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM. |
In vitro study | BMS-1166 was less toxic to the cell lines tested, preventing the interaction of soluble PD-L1 with the PD-1 receptor expressed on the cell surface. BMS-1166 attenuated PD-L1 inhibition of T cell receptor-mediated T lymphocyte activation. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.56 ml | 7.799 ml | 15.598 ml |
5 mM | 0.312 ml | 1.56 ml | 3.12 ml |
10 mM | 0.156 ml | 0.78 ml | 1.56 ml |
5 mM | 0.031 ml | 0.156 ml | 0.312 ml |