170277-31-3
Infliximab
CAS: 170277-31-3
Molecular Formula:
170277-31-3 - Names and Identifiers
170277-31-3 - Physico-chemical Properties
| Storage Condition | Room Temprature |
| In vitro study | TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition. |
| In vivo study | A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α +/+ ) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab. |
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Product Name: Infliximab Visit Supplier Webpage Request for quotationCAS: 170277-31-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: Infliximab Visit Supplier Webpage Request for quotationCAS: 170277-31-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Infliximab Visit Supplier Webpage Request for quotationCAS: 170277-31-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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CAS: 170277-31-3
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Email: 3008007409@qq.com
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CAS: 170277-31-3
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View History
170277-31-3
tert-butyl (2-(2,2,2-trifluoroacetamido)ethyl)carbamate
2-Amino-2-(p-tolyl)propanoic acid
1H-Indole-3-carboxaldehyde,2-(2-ethoxyphenyl)-(9CI)
4-(1-benzofuran-2-ylcarbonyl)-3-hydroxy-1-{5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one
86008-21-1
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carboxylate
1,2,4,3,5-Trithiadiborolane, 3,5-dimethyl-
1-(3-Pyridinyl)-3-buten-1-ol
P-N-HEXYLPHENOL
tert-butyl (2-(2,2,2-trifluoroacetamido)ethyl)carbamate
2-Amino-2-(p-tolyl)propanoic acid
1H-Indole-3-carboxaldehyde,2-(2-ethoxyphenyl)-(9CI)
4-(1-benzofuran-2-ylcarbonyl)-3-hydroxy-1-{5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one
86008-21-1
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carboxylate
1,2,4,3,5-Trithiadiborolane, 3,5-dimethyl-
1-(3-Pyridinyl)-3-buten-1-ol
P-N-HEXYLPHENOL