1701-69-5 - Names and Identifiers
1701-69-5 - Physico-chemical Properties
Molecular Formula | C8H9NO
|
Molar Mass | 135.16 |
Density | 1.034 |
Boling Point | 89-90°C 2mm |
Flash Point | 89-90°C/2mm |
Vapor Presure | 0.0684mmHg at 25°C |
BRN | 111366 |
pKa | 2.75±0.26(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.5220 |
MDL | MFCD00041229 |
1701-69-5 - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | R22 - Harmful if swallowed
R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
|
Safety Description | S24/25 - Avoid contact with skin and eyes.
S39 - Wear eye / face protection.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
|
RTECS | UC3800000 |
1701-69-5 - Introduction
4-propionylpyriridine is an organic compound with the chemical formula C8H9NO and the structural formula CH3COC5H4N. The following is a description of its nature, use, preparation and safety information:
Properties: 4-propionylpyriridine is a colorless to pale yellow liquid with a weak special odor at room temperature. It has high solubility and is soluble in a variety of organic solvents such as Alcohols, Ketones and ethers. It has a melting point of 17-18°C and a boiling point of 233-234°C.
Uses: 4-propionylpyriridine is widely used in acylation and acetylation reactions in organic synthesis reactions. It can be used as an esterification agent, an acetylation agent and an acylation agent for the synthesis of acyl-containing compounds. In addition, it can also be used as antioxidants, dye intermediates and pharmaceutical intermediates.
preparation method: usually, 4-propionylpyriridine can be prepared by condensation reaction of pyridine and propionyl chloride. First, pyridine is dissolved in a suitable solvent, such as dimethylformamide. Subsequently, propionyl chloride was added slowly while maintaining the reaction temperature at 0-5°C. At the end of the reaction, the pure 4-Propionylpyridine product is obtained by distillation.
Safety information: When using 4-propionylpyriridine, you need to pay attention to the following safety matters. It is an irritating compound, avoid contact with skin and eyes. Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats during operation. During storage and handling, contact with oxidants, acids and other substances should be avoided to avoid dangerous reactions. When accidental leakage occurs, appropriate measures should be taken in time to clean up and deal. Follow proper laboratory procedures and personal protective measures.
Last Update:2024-04-09 21:01:54