166524-65-8 - Names and Identifiers
166524-65-8 - Physico-chemical Properties
Molecular Formula | C6H6F2N2O
|
Molar Mass | 160.12 |
Density | 1.282±0.06 g/cm3(Predicted) |
Boling Point | 207.5±43.0 °C(Predicted) |
Flash Point | 79.286°C |
Vapor Presure | 0.323mmHg at 25°C |
pKa | -5.14±0.30(Predicted) |
Storage Condition | RT, dry |
Refractive Index | 1.453 |
166524-65-8 - Introduction
2-ETHOXY-4,6-DIFLUOROPYRIMIDINE is an organic compound with the chemical formula C6H6F2N2O. The following is a description of its nature, use, preparation and safety information:
Nature:
2-ETHOXY-4,6-DIFLUOROPYRIMIDINE is a white crystalline solid with special chemical properties. Its melting point is about 70-75 degrees Celsius, insoluble in water, soluble in ethanol and carbon disulfide. It is a weakly alkaline compound.
Use:
2-ETHOXY-4,6-DIFLUOROPYRIMIDINE has important application value in organic synthesis. It can be used as a synthetic intermediate for pesticides and glyphosate. In addition, it can also be used as raw materials and intermediates in the fields of dyes, pigments and pharmaceuticals.
Method:
There are two main methods for the preparation of 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE:
1.2-fluoro-4, 6-dibromopyrimidine and ethanol are used to react to form 2-ethoxy-4, 6-dibromopyrimidine, and then the bromine atom is replaced by a fluorine atom by hydrofluoric acid, the target product is obtained.
2. Using 2-fluoro-4, 6-dinitropyrimidine and ethanol to react, the intermediate 2-ethoxy-4, 6-dinitropyrimidine is generated, and then through reduction reaction and fluorination reaction, stepwise conversion of the nitro group to a fluorine atom finally gives 2-ETHOXY-4,6-DIFLUOROPYRIMIDINE.
Safety Information:
2-ETHOXY-4,6-DIFLUOROPYRIMIDINE needs to be safe during operation and storage. It is a toxic compound that can cause damage to the human body. Contact with the skin, inhalation of its dust or vapor should be avoided. Wear appropriate protective measures such as protective gloves, glasses and protective face masks when using or handling the substance. At the same time, it should be operated in a well-ventilated environment and avoid contact with oxidants and acids. In case of accidental exposure or accident, corresponding first aid measures should be taken quickly and professional doctors should be consulted.
Last Update:2024-04-09 21:11:58