1643378-54-4 - Names and Identifiers
1643378-54-4 - Physico-chemical Properties
1643378-54-4 - Introduction
rac-(1R,2S)-2-(2,5-difluorophenyl)cyclopropan-1-amine hydrochloride, trans(rac-(1R,2S)-2-(2,5-difluorophenyl)cyclopropan-1-amine chloride, trans) is a compound that has the following properties:
Nature:
-Appearance: White solid
-Molecular formula: C9H11ClF2N
-Molecular weight: 215.64g/mol
-Melting point: 134-136 ° C
-trans isomer: benzene ring containing two fluorine atoms on the same side
Use:
- rac-(1R,2S)-2-(2,5-difluorophenyl)cyclopropan-1-amine hydrochloride, trans is commonly used as a raw material or intermediate in organic synthesis reactions, especially widely used in the field of medicine.
-It can be used to synthesize biologically active compounds, such as potential pharmaceutical compounds or ligands.
Method:
The preparation of-rac-(1R,2S)-2-(2,5-difluorophenyl)cyclopropan-1-amine hydrochloride, trans generally involves the following steps:
1.2,5-difluorobenzoic acid was reacted with malonic anhydride by selective substitution to synthesize propyl 2,5-difluorobenzoate.
2.2,5-difluorobenzoic acid propyl ester is reacted with potassium hydroxide (KOH) in dichloromethane to generate 2,5-difluorobenzoic acid.
3.2,5-difluorobenzoic acid is converted to 2,5-difluorophenyl ethanol by reduction reaction.
4.2,5-difluorophenyl ethanol is reacted with ferric chloride (FeCl3) and bromine in tetrahydrofuran to give 2,5-difluorophenyl bromide.
5. Through the Grignard reaction, 2,5-difluorophenyl bromide and tin dioxide (SnO2) were reacted in acetic acid to synthesize trans-2-(2,5-difluorophenyl) cyclopropane -1-amine.
6. Trans-2-(2,5-difluorophenyl) cyclopropane-1-amine reacts with hydrochloric acid to yield rac-(1R,2S)-2-(2,5-difluorophenyl) cyclopropane -1-amine hydrochloride.
Safety Information:
- rac-(1R,2S)-2-(2,5-difluorophenyl)cyclopropan-1-amine hydrochloride, trans has low toxicity under reasonable use.
-When handling and handling, follow appropriate laboratory practices and wear appropriate personal protective equipment, such as gloves and eye protection.
-If ingestion or contact with skin and eyes, rinse immediately with plenty of water and seek medical help.
Last Update:2024-04-09 15:18:04