1626387-80-1
AZD3759
CAS: 1626387-80-1
Molecular Formula: C22H23ClFN5O3
1626387-80-1 - Names and Identifiers
1626387-80-1 - Physico-chemical Properties
| Molecular Formula | C22H23ClFN5O3 |
| Molar Mass | 459.9 |
| Density | 1.358±0.06 g/cm3(Predicted) |
| Boling Point | 571.4±50.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 6.71±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In H3255 (L858R) cells, AZD3759 inhibits EGFR phosphorylation with an IC50 of 7.2 nM. AZD3759 showed an inhibitory effect on the proliferation of PC-9 and H3255 cells derived from pEGFR pathway and EGFR mutant gene, with IC50 of 7.7 nM and 7 nM, respectively, and had no activity on the proliferation of H838 cells. |
| In vivo study | AZD3759 showed good oral activity in dogs and was able to penetrate extensively into the monkey brain. In the brain metastatic PC-9 (Exon19Del) model, AZD3759 (15 mg/kg) caused a significant dose-dependent antitumor effect. |
1626387-80-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.174 ml | 10.872 ml | 21.744 ml |
| 5 mM | 0.435 ml | 2.174 ml | 4.349 ml |
| 10 mM | 0.217 ml | 1.087 ml | 2.174 ml |
| 5 mM | 0.043 ml | 0.217 ml | 0.435 ml |
Last Update：2024-01-02 23:10:35
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View History
1626387-80-1
N-[2-chloro-6-(trifluoromethyl)phenyl]-1,3-thiazolidine-4-carboxamide
6-amino-5-cyano-5'-fluoro-2'-oxo-3-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)
438625-26-4
4-Chloro-2,3-dihydro-7-hydroxy-1H-inden-1-one
1220040-27-6
438472-80-1
2246890-21-9
83949-61-5
(2-HYDROXYMETHYL-4,5-DIIODO-PHENYL)-METHANOL
N-[2-chloro-6-(trifluoromethyl)phenyl]-1,3-thiazolidine-4-carboxamide
6-amino-5-cyano-5'-fluoro-2'-oxo-3-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)
438625-26-4
4-Chloro-2,3-dihydro-7-hydroxy-1H-inden-1-one
1220040-27-6
438472-80-1
2246890-21-9
83949-61-5
(2-HYDROXYMETHYL-4,5-DIIODO-PHENYL)-METHANOL