Molecular Formula | C13H10OS |
Molar Mass | 214.28 |
Density | 1.262±0.06 g/cm3(Predicted) |
Boling Point | 125-140 °C(Press: 0.05 Torr) |
Flash Point | 178.2°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 1.06E-05mmHg at 25°C |
Appearance | Brown Semi-Solid |
Storage Condition | Refrigerator |
Refractive Index | 1.644 |
Physical and Chemical Properties | Liquid compounds. Boiling point 165-180 °c/27-68PA, refractive index (nD22)1.6520-6548. |
Use | An intermediate of ketotifen and thiacridine. |
Use | An intermediate of ketotifen and phenyclidine. |
Production method | Thiophene is chloromethylated with formaldehyde and concentrated hydrochloric acid to generate 2-(chloromethyl) thiophene, and then heated with triethyl phosphite to obtain 2-thiophene methylphosphonic acid diethyl ester, which is condensed with o-carboxybenzaldehyde under the participation of sodium methoxide to obtain 2-[β-(2-thiophene) vinyl] benzoic acid; then it is catalyzed by palladium-carbon hydrogenation, reduction of vinyl, and finally cyclization under the action of polyphosphoric acid to obtain the product. |