1603-91-4
2-Amino-4-methylthiazole
CAS: 1603-91-4
Molecular Formula: C4H6N2S
1603-91-4 - Names and Identifiers
| Name | 2-Amino-4-methylthiazole |
| Synonyms | Nomortiroide Normotiroide 4-methylthiazol-2-amine 4-Methylthiazole-2-amine 2-Amino-4-methylthiazole 2-Thiazolamine, 4-methyl- 4-methylthiazol-2-ylamine 4-Methyl-thiazol-2-ylamine Thiazole, 2-amino-4-methyl- 4-methyl-1,3-thiazol-2-amine |
| CAS | 1603-91-4 |
| EINECS | 216-505-6 |
| InChI | InChI=1/C4H6N2S/c1-3-2-7-4(5)6-3/h2H,1H3,(H2,5,6) |
| InChIKey | OUQMXTJYCAJLGO-UHFFFAOYSA-N |
1603-91-4 - Physico-chemical Properties
| Molecular Formula | C4H6N2S |
| Molar Mass | 114.17 |
| Density | 1.176 (estimate) |
| Melting Point | 44-47 °C (lit.) |
| Boling Point | 231-232 °C (lit.) |
| Flash Point | >230°F |
| Water Solubility | soluble |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.059mmHg at 25°C |
| Appearance | Solid |
| Color | White to Yellow to Green |
| Merck | 14,450 |
| BRN | 107890 |
| pKa | 5.36±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00005329 |
| Physical and Chemical Properties | White crystals. Melting point 45-45 °c, boiling point 281-282 °c (decomposition),124-126 °c (2.67kPa),70 °c (53.3). Very soluble in water, ethanol and ether. |
| Use | Used as a pharmaceutical Intermediate |
1603-91-4 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/37 - Irritating to eyes and respiratory system. R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29341000 |
| Hazard Class | IRRITANT |
1603-91-4 - Nature
Open Data Verified Data
white crystals. Melting point 45~46 ℃, boiling point 281~282 ℃ (decomposition),124~126 ℃(2. 7kPa),70 ℃(53. 3Pa). Very soluble in water, ethanol and ether.
Last Update：2024-01-02 23:10:35
1603-91-4 - Preparation Method
Open Data Verified Data
derived from the action of chloroacetone and thiourea. The process is to add water and thiourea to the reactor with stirring. Chloroacetone is added dropwise within 5H; Thiourea is gradually dissolved as the reaction proceeds; Then the reaction is refluxed for 2H, and granular sodium hydroxide is added under cooling and slowly stirring; Then the upper oil layer is separated out, and the water layer is extracted with diethyl ether; the dark red oil was combined with the extract, dried with sodium hydroxide and filtered; After ether was distilled off from the filtrate, the residue was distilled under reduced pressure to collect 117-120 °c (1. lkPa), or 130~133 C (2.4kPa) fraction to obtain the product, the yield of 70% ~ 75%.
Last Update：2022-01-01 10:57:32
1603-91-4 - Use
Open Data Verified Data
This product is used in organic synthesis, manufacturing medicine and other fine chemical products.
Last Update：2022-01-01 10:57:32
1603-91-4 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | for organic synthesis. Used as a pharmaceutical intermediate |
| production method | is obtained by the action of chloroacetone and thiourea. Add water and thiourea to the reactor, stir, and drop chloroacetone within half an hour. As the reaction progresses, thiourea gradually dissolves. Reflux reaction for 2h, under cooling and slowly stirring, adding granular sodium hydroxide. Then the upper oil layer is separated, the water layer is extracted with ether, the dark red oil is combined with the extract, dried with sodium hydroxide, and filtered. After the ether is distilled from the filtrate, the residue is distilled under reduced pressure, and the product is obtained by collecting the fraction of 117-120 ℃(1.07kPa) or 130-133 ℃(2.40kPa) with a yield of 70-75%. |
Last Update：2024-04-09 20:52:54
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View History
1603-91-4
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