159857-79-1
Val-cit-PAB-OH
CAS: 159857-79-1
Molecular Formula: C18H29N5O4
159857-79-1 - Names and Identifiers
159857-79-1 - Physico-chemical Properties
| Molecular Formula | C18H29N5O4 |
| Molar Mass | 379.45 |
| Density | 1.243±0.06 g/cm3(Predicted) |
| Melting Point | 168 °C(dec.) |
| Boling Point | 715.0±60.0 °C(Predicted) |
| Solubility | DMSO :59 mg/mL (155.49 mM) |
| pKa | 13.75±0.46(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Physical and Chemical Properties | Bioactive Val-cit-PAB-OH is a degradable ADC linker. |
| Use | The VAL-CIT-PAB is used as a reagent to prepare cell penetrating peptide GRP78 ligand for tumor cell-specific prodrug therapy, and to prepare monomethylvaline derivative ligand and antibody for cancer therapy. |
159857-79-1 - Upstream Downstream Industry
159857-79-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.635 ml | 13.177 ml | 26.354 ml |
| 5 mM | 0.527 ml | 2.635 ml | 5.271 ml |
| 10 mM | 0.264 ml | 1.318 ml | 2.635 ml |
| 5 mM | 0.053 ml | 0.264 ml | 0.527 ml |
Last Update：2024-01-02 23:10:35
159857-79-1 - Reference Information
| Use | VAL-CIT-PAB is used as a reagent to prepare the cell penetrating peptide GRP78 ligand for tumor cell-specific prodrug therapy, and to prepare monomethylvaline derivative ligands and antibodies for cancer treatment. |
| biological activity | Val-cit-PAB-OH is a degradable ADC linker. |
| target | Cleavable |
Last Update：2024-04-09 21:54:55
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View History
159857-79-1
5940-03-4
ethyl 4-(2-chloroanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
尼莫地平杂质16
间苯三酚杂质 42
N-(2-Hydroxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide
3,5-Dibromo-2-chlorotrifluoromethoxybenzene
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
571174-12-4
5940-03-4
ethyl 4-(2-chloroanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
尼莫地平杂质16
间苯三酚杂质 42
N-(2-Hydroxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide
3,5-Dibromo-2-chlorotrifluoromethoxybenzene
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
571174-12-4
Raw Materials for 159857-79-1
L-Ornithinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
Boc-Val-Cit-PABA
FMOC-L-Valine
L-Citrulline
L-Ornithine, N5-(aMinocarbonyl)-N2-[N-[(9H-fluoren-9-ylMethoxy)carbonyl]-L-valyl]-
FMOC-VAL-OPFP
FMoc-Val-Cit-PAB
FMOC-VAL-OSU
Fmoc-Cit-PABA
Boc-Val-Cit-PABA
FMOC-L-Valine
L-Citrulline
L-Ornithine, N5-(aMinocarbonyl)-N2-[N-[(9H-fluoren-9-ylMethoxy)carbonyl]-L-valyl]-
FMOC-VAL-OPFP
FMoc-Val-Cit-PAB
FMOC-VAL-OSU
Fmoc-Cit-PABA
Downstream Products for 159857-79-1
MC-Val-Cit-PAB
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-