Molecular Formula | C28H39N3O2 |
Molar Mass | 449.63 |
Density | 1.040 |
Melting Point | 122-123°C |
Boling Point | 564.8±50.0 °C(Predicted) |
Solubility | DMSO: soluble |
Appearance | solid |
Color | off-white |
pKa | 7.29±0.10(Predicted) |
Storage Condition | Store at RT |
Stability | Store in Freezer |
In vitro study | SNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC 50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors. |
In vivo study | SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan. Animal Model: Male and female C57BL6/J mice (20-30g) injected with Sumatriptan Dosage: 10 mg/kg Administration: Intraperitoneal injection; once Result: Significantly attenuated allodynia. |
WGK Germany | 3 |