1550053-02-5
BRD3308
CAS: 1550053-02-5
Molecular Formula: C15H14FN3O2
1550053-02-5 - Names and Identifiers
1550053-02-5 - Physico-chemical Properties
| Molecular Formula | C15H14FN3O2 |
| Molar Mass | 287.29 |
| Density | 1.382±0.06 g/cm3(Predicted) |
| Boling Point | 449.9±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 12.13±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. The selectivity of BRD3308 to HDAC3 is 23 times higher than that of HDAC1 (IC50 is 1.26 μM) or HDAC2 (IC50 is 1.34 μM). BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress and increases functional insulin release. BRD3308 can also activate HIV-1 transcription and destroy HIV-1 latency. |
1550053-02-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.481 ml | 17.404 ml | 34.808 ml |
| 5 mM | 0.696 ml | 3.481 ml | 6.962 ml |
| 10 mM | 0.348 ml | 1.74 ml | 3.481 ml |
| 5 mM | 0.07 ml | 0.348 ml | 0.696 ml |
Last Update：2024-01-02 23:10:35
1550053-02-5 - Reference Information
| biological activity | BRD3308 is a potent, highly selective inhibitor of HDAC3, the IC50 values for HDAC1 and HDAC2 were 54 nM, 1.26 μm and 1.34 μm, respectively. BRD3308 can activate HIV-1 transcription. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines (glycolipid toxicity stress) and increases the release of functional insulin. |
| Target | Value |
| HDAC3 (Cell-free assay) | 54 nM |
| HDAC1 (Cell-free assay) | 1.26 μM |
| HDAC2 (Cell-free assay) | 1.34 μM |
Last Update：2024-04-09 21:04:16
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Product Name: Brd3308 Visit Supplier Webpage Request for quotationCAS: 1550053-02-5
Tel: +86-400-900-4166
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QQ: 2881950922
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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WhatsApp: +86-18821248368
Spot supply
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View History
1550053-02-5
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2-METHYL-2-THIOPSEUDOUREA SULFATE
N-(二氨基亚甲基)-2-甲基-5-(甲基磺酰基)-4-(1H-吡咯-1-基)苯甲酰胺
ETHYL 4-OXO-7-PHENYL-4H-PYRIMIDO[1,2-B]PYRIDAZINE-3-CARBOXYLATE
2-氨甲基吗啉盐酸盐
3-(3-AMINOMETHYL-AZETIDIN-1-YL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
20027-13-8
103392-01-4
(S)-3-AMino-2,2-difluoro-3-(4-fluorophenyl)propionic acid HCl
Ethyl 3-Cyclohexenecarboxylate