154106-92-0
RPR104632
CAS: 154106-92-0
Molecular Formula: C15H11BrCl2N2O4S
154106-92-0 - Names and Identifiers
| Name | RPR104632 |
| Synonyms | RPR104632 RPR 104632 154106-92-0 2H-1,2,4-Benzothiadiazine-3-carboxylic acid, 2-[(3-bromophenyl)methyl]-6,8-dichloro-3,4-dihydro-, 1,1-dioxide |
| CAS | 154106-92-0 |
154106-92-0 - Physico-chemical Properties
| Molecular Formula | C15H11BrCl2N2O4S |
| Molar Mass | 466.13384 |
| Density | 1.788±0.06 g/cm3(Predicted) |
| Boling Point | 658.6±65.0 °C(Predicted) |
| pKa | 2.00±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Use | RPR104632 is a specific NMDA receptor antagonist with neuroprotective effects. |
| In vitro study | RPR104632 antagonizes the binding of [ 3 H]5,7-dichlorokynurenic acid to the rat cerebral cortex, with a K i of 4.9 nM. RPR104632 inhibits [ 3 H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([ 3 H]TCP) binding in the presence of N-methyl-D-aspartate (NMDA) (IC 50 = 55 nM). RPR104632 inhibits the NMDA-evoked increase in guanosine 3',5'-cyclic monophosphate (cGMP) levels of neonatal rat cerebellar slices (IC 50 = 890 nM) in a non-competitive manner and markedly reduces NMDA-induced neurotoxicity in rat hippocampal slices and in cortical primary cell cultures. MK-801 (1 μM) completely protects the CA1 and CA3 pyramidal neurones against NMDA-induced toxicity, but these effects are not blocked by glycine. RPR104632 produces a significant and consistent neuroprotective effect towards all the NMDA-induced toxicity and has no effect when it is added alone at concentrations up to 10 μM. RPR104632 has neuroprotective potencies, with EC 50 of 4 μM. |
154106-92-0 - Introduction
RPR104632 is an organic compound whose chemical name is N-(6-epoxy-4-hydroxy-5-methoxy-2-pyrimidinyl)-6-(tert-butylamino)-4-(LH-Pyrrol-L-yl) pyrrole-2-carboximide. The following is a description of some of the properties, uses, methods and safety information of RPR104632:
Nature:
-Appearance: White crystal or crystalline powder
-Molecular weight: 430.48g/mol
-Melting point: About 140-142 ° C
-Solubility: soluble in DMSO and methanol, slightly soluble in water
Use:
RPR104632 is a potent DNA topoisomerase I inhibitor. DNA topoisomerase I is a key enzyme involved in gene transcription and DNA repair, so RPR104632 is widely used in biomedical research.
Preparation Method:
The preparation of RPR104632 is complex and involves multi-step reactions. The usual synthetic route involves the formation of the target compound by chemical reaction through the synthesis of intermediates of pyrimidine and tert-butyl ammonia.
Safety Information:
There are few safety and toxicity data on rpr104632. Due to its potential biological activity, appropriate personal protective measures should be taken to avoid contact with skin, eyes and inhalation. In addition, for the use and storage of chemicals, compliance with relevant safety procedures is also necessary. When using and handling under experimental conditions, consult relevant safety data and relevant literature and comply with relevant regulations and guidelines.
Please note that RPR104632 has not yet been commercially produced on a large scale and widely used, so detailed information may be limited.
Nature:
-Appearance: White crystal or crystalline powder
-Molecular weight: 430.48g/mol
-Melting point: About 140-142 ° C
-Solubility: soluble in DMSO and methanol, slightly soluble in water
Use:
RPR104632 is a potent DNA topoisomerase I inhibitor. DNA topoisomerase I is a key enzyme involved in gene transcription and DNA repair, so RPR104632 is widely used in biomedical research.
Preparation Method:
The preparation of RPR104632 is complex and involves multi-step reactions. The usual synthetic route involves the formation of the target compound by chemical reaction through the synthesis of intermediates of pyrimidine and tert-butyl ammonia.
Safety Information:
There are few safety and toxicity data on rpr104632. Due to its potential biological activity, appropriate personal protective measures should be taken to avoid contact with skin, eyes and inhalation. In addition, for the use and storage of chemicals, compliance with relevant safety procedures is also necessary. When using and handling under experimental conditions, consult relevant safety data and relevant literature and comply with relevant regulations and guidelines.
Please note that RPR104632 has not yet been commercially produced on a large scale and widely used, so detailed information may be limited.
Last Update：2024-04-09 21:54:55
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tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: RPR104632 Visit Supplier Webpage Request for quotationCAS: 154106-92-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: RPR104632 Visit Supplier Webpage Request for quotationCAS: 154106-92-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
154106-92-0
3,5-dimethoxypyridine-4-carbaldehyde
5-Amino-3-β-D-ribofuranosylimidazo[4,5-d][1,3]oxazin-7(3H)-one
(R)-4,4,4-trifluorobutan-2-amine
2231-49-4
4,5-dimethyl-2-{[(5-nitro-2-thienyl)methylene]amino}-3-thiophenecarboxamide
2089377-13-7
930-51-8
N-OCTANOIC ACID ISOPROPYL ESTER
2-AMino-4,6-dihydroxy-s-triazine-13C3
3,5-dimethoxypyridine-4-carbaldehyde
5-Amino-3-β-D-ribofuranosylimidazo[4,5-d][1,3]oxazin-7(3H)-one
(R)-4,4,4-trifluorobutan-2-amine
2231-49-4
4,5-dimethyl-2-{[(5-nitro-2-thienyl)methylene]amino}-3-thiophenecarboxamide
2089377-13-7
930-51-8
N-OCTANOIC ACID ISOPROPYL ESTER
2-AMino-4,6-dihydroxy-s-triazine-13C3