Name | Cartap hydrochloride |
Synonyms | PADAN(R) SUNVEX(R) SUNTAP(R) Cartap hydrochloride CARTAP HYDROCHLORIDE CADAN(R) HYDROCHLORIDE VEGETOX(R) HYDROCHLORIDE S,S'2-DIMETHYLAMINOTRIMETHYLENE BIS-(THIOCARBAMATE) HYDROCHLORIDE S,S'-[2-(dimethylamino)-1,3-propanediyl] dicarbamothioate hydrochloride |
CAS | 15263-52-2 |
EINECS | 239-309-2 |
Molecular Formula | C7H16ClN3O2S2 |
Molar Mass | 273.8 |
Density | 1.4008 (rough estimate) |
Water Solubility | ca. 200 g l-1 (20 °C, pH 5) |
Vapor Presure | Negligible |
Appearance | neat |
BRN | 5157539 |
pKa | 7.61 (base) |
Refractive Index | 1.6100 (estimate) |
Physical and Chemical Properties | Icarol is usually made into hydrochloride, which has a white crystal appearance and a slight odor. M. p.183 ~ 183.5 ℃ (decomposition) (melting point of the original drug is 179~181 ℃). Slightly soluble in methanol, insoluble in ethanol, insoluble in organic solvents such as acetone, ether, chloroform, hexane, benzene, etc.; the solubility in water at 25°C is 200g/L. It is stable in acidic medium and unstable in alkaline medium. Storage at 40 ℃ and 60 ℃ for 3 months without change, closed storage at room temperature without change, slightly hygroscopic, corrosive to iron and other metals. The dissolution point of free alkali is 130.5~131 ℃. |
Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S2 - Keep out of the reach of children. S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | 2771 |
WGK Germany | 3 |
RTECS | FD1225000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 oral in rat: 250mg/kg |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
toxicity | Acute oral LD50 of male rats is 345mg/kg, female is 325mg/kg, acute oral LD50 in mice was 192mg/kg; Acute percutaneous LD50>1000mg/kg in rats and mice; Acute inhalation LC50>4.5mg/L in male rats. Mild irritation to eyes and skin. Rats fed for 2 years had no effect at a dose of 10mg/kg per day. No carcinogenic, teratogenic, mutagenic effects. Carp LC50 was 1.3mg/L (48 h0. Low toxicity to bees, toxic to Silkworm, low toxicity to birds, safe to natural enemies such as spiders. |
uses | The Silkworm toxin insecticide has strong killing and gastric toxicity, it invades the junction of nerve cells, block the acetylcholine secreted by the former nerve cell to communicate to the latter nerve cell, and make the nerve cell not excited, so that the insect nerve paralysis, can not eat, can not move, stop the development, resulting in death. It has good control effect on both Chilo suppressalis and Chilo suppressalis, and can also cure rice leaf roller, leaf hopper, slime worm, etc. Rice Chilo suppressalis and Chilo suppressalis were sprayed with 50% soluble powder 1000~1500 times, Rice bract and rice leaf roller were sprayed with 1000 times of the liquid medicine, and rice borer was sprayed with the liquid, yellow bar snapping nail, citrus leaf moth, onion thrips, etc. with 1000 times liquid spray. as an insecticide, it has the advantages of high efficiency, broad spectrum, low toxicity and low residue, and has many functions such as internal absorption, stomach poison and contact killing. Can Control rice stem borer, rice leaf roller Borer, Rice bract, rice leaf fly, rice straw rope and vegetable cabbage worm, cabbage butterfly, pear polyphagia, citrus leaf moth and other pests. Dosage of 30-50g per mu. It is used to control rice stem borer, rice leaf roller, Rice bract, rice leaf fly, rice stem fly, vegetable cabbage cabbage worm, pterocellothorax, pear polyphagia, citrus leaf moth, etc. |
production method | is derived from the Amination of chloropropene with dimethylamine, chlorination of chlorine gas, and thiocyanation of sodium thiosulfate and sodium cyanide. amination reaction 40% dimethylamine and 40% alkali solution were dropped into allyl chloride at 0~15 ℃ for about 0.5H, then the solution was kept at 45 ℃ for 2H, the layer was allowed to stand to obtain N,N-dimethylpropylamine. The raw material ratio is: allyl chloride: dimethylamine: sodium hydroxide = 1:1.2:1.3(mol). The yield was 82%. Chlorination reaction the dried hydrogen chloride gas was introduced into a solution of allylamine and chloroform at 0 to 10 °c. Then, chlorine gas was passed through at 20 ° C., the mixture was allowed to stand still, and the chloroform layer was separated. Then, the solid chloride was sufficiently dissolved in water again, and the mixture was allowed to stand still for 0.5h to separate the residual chloroform. The yield of the chlorination product 1-N, n-dimethyl-2, 3-dichloropropylamine hydrochloride was 91.32. The ratio of allylamine to hydrogen chloride and chlorine is 1:1:(1~1.05), and the dosage of chloroform is 250L per thousand Mol. The thiocyanation reaction first drops the alkali solution into the chloride aqueous solution, and then drops the sodium thiosulfate. The temperature was then raised to 60 °c and incubated at 60-65 °c for 4H. The sulfonated compound is pumped into the cyanidation kettle, and sodium cyanide solution is dropped into it at 13~15 ℃, then the reaction is maintained for 1H, centrifuged, washed salt at low temperature, and centrifuged to obtain 2-N,N-dimethyl -1, 3-dithiocyanopropane. The raw material ratio is chloride: sodium thiosulfate: sodium cyanide = 1:2.08:2.3. The amount of sodium hydroxide used was the total acidity of the chloride aqueous solution (mg/mL)× the charged amount (L)× 0.972. Sulfonation temperature 60 C, time 4H; Cyanide temperature (13±2) c, Time 1h. Or 1-N, n-dimethyl-2, 3-dichloropropylamine hydrochloric acid is prepared by thiocyanate reaction with thiocyanate in methanol first in base and free base. Alcoholysis reaction after the thiocyanate and methanol are mixed, the temperature is cooled to 0 ℃, dry hydrogen chloride is introduced, the temperature is kept at 0~10 ℃, the temperature is raised to 50 ℃, and the reaction is kept for 3H, the temperature was cooled to 0 ℃, then kept for 2H, centrifuged, the product was dried, the filtrate was to be recovered, and the yield was 96%. The raw material ratio of alcoholysis is sulfide: HC1 = 1:10, and the amount of methanol is 450L/1000mol of Thio. |
category | pesticide |
toxicity grade | high toxicity |
Acute toxicity | oral-rat LD50: 250 mg/kg; Oral-mouse LD50: 165 mg/kg |
flammability hazard characteristics | toxic nitrogen oxides, hydrogen chloride, and oxysulfides gases from combustion |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
extinguishing agent | dry powder, foam, sand |