152126-33-5 - Names and Identifiers
152126-33-5 - Physico-chemical Properties
Molecular Formula | C6H4FNO2
|
Molar Mass | 141.1 |
Density | 1.419±0.06 g/cm3(Predicted) |
Boling Point | 284.9±20.0 °C(Predicted) |
Flash Point | 126.1°C |
Vapor Presure | 0.00136mmHg at 25°C |
pKa | 1.27±0.10(Predicted) |
Storage Condition | Room Temprature |
Refractive Index | 1.541 |
152126-33-5 - Introduction
4-FLUORONICOTINIC ACID, chemical formula C6H4FNO2, is an organic compound containing fluorine and carboxyl groups. The following is a description of the nature, use, preparation and safety information of 4-FLUORONICOTINIC ACID:
Nature:
1. Appearance: 4-FLUORONICOTINIC ACID is a white crystalline solid.
2. Melting point: About 140-144 degrees Celsius.
3. Solubility: Soluble in most organic solvents, such as ethanol, dimethyl sulfoxide, etc.
Use:
4-FLUORONICOTINIC ACID is an important organic intermediate, which is widely used in drug synthesis and pesticide synthesis. It has the following uses:
1. Drug synthesis: can be used for the synthesis of antidepressant drugs, anti-gout drugs, anticancer drugs.
2. Pesticide Synthesis: can be used for synthetic pesticides, fungicides, etc.
Method:
The preparation of 4-FLUORONICOTINIC ACID is usually carried out by the following steps:
1. Obtain fluorobenzene (C6H5F) as raw material.
2. Under acidic conditions, fluorobenzene reacts with sodium cyanide (NaCN) to generate 4-fluoropyridine (C5H4NF).
3. 4-fluoropyridine is reacted with acidic solution to obtain 4-FLUORONICOTINIC ACID.
Safety Information:
1. 4-FLUORONICOTINIC ACID may be irritating to eyes, skin and respiratory tract. Contact with eyes, skin and inhalation of vapors should be avoided.
2. Wear protective gloves, goggles and protective masks during operation to ensure well-ventilated experimental conditions.
3. Keep the storage container airtight, store in a cool, dry place, away from fire and oxidant.
4. If accidental contact or misuse, please seek medical help immediately, and bring the package or label to the doctor.
5. In the process of use and disposal, it is necessary to comply with relevant safety operation procedures and laws and regulations.
Last Update:2024-04-09 15:17:52