Name | Pemigatinib |
Synonyms | Pemigatinib INCB-054828 |
CAS | 1513857-77-6 |
Molecular Formula | C₂₄H₂₇F₂N₅O₄ |
Molar Mass | 487.50 |
Density | 1.44±0.1 g/cm3(Predicted) |
Boling Point | 697.6±55.0 °C(Predicted) |
Solubility | soluble in DMSO |
pKa | 11.56±0.40(Predicted) |
Storage Condition | -20℃ |
Physical and Chemical Properties | Bioactive Pemigatinib (INCB054828, Pemazyre) is a selective inhibitor of oral active FGFR. The IC50 for FGFR1, FGFR2, FGFR3 and FGFR4 is 0.4 nM, 0.5 nM, 1.2 nM and 30 nM respectively. Pemigatinib(INCB054828) has the potential to treat cholangiocarcinoma. |
Use | Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor. The IC50 for FGFR1,FGFR2,FGFR3,FGFR4 is 0.4 nM,0.5 nM,1.2 nM,30 nM, respectively. Pemigatinib has the potential for cholangiocarcinoma. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.051 ml | 10.256 ml | 20.513 ml |
5 mM | 0.41 ml | 2.051 ml | 4.103 ml |
10 mM | 0.205 ml | 1.026 ml | 2.051 ml |
5 mM | 0.041 ml | 0.205 ml | 0.41 ml |