Molecular Formula | C24H28O4 |
Molar Mass | 380.48 |
Solubility | DMSO: >28mg/mL (warmed) |
Appearance | powder |
Color | white to off-white |
Storage Condition | Store at -20°C |
In vitro study | Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors. |
In vivo study | SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate. Animal Model: Sprague-Dawley rats Dosage: 25 mg/kg Administration: I.p.; daily from post-natal days 5 to 15 Result: Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |
WGK Germany | 3 |