Molecular Formula | C10H11NO4 |
Molar Mass | 209.2 |
Density | 1.390±0.06 g/cm3(Predicted) |
Boling Point | 425.3±40.0 °C(Predicted) |
pKa | 1.76±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
In vitro study | MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3). |
In vivo study | (RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons. Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.78 ml | 23.901 ml | 47.801 ml |
5 mM | 0.956 ml | 4.78 ml | 9.56 ml |
10 mM | 0.478 ml | 2.39 ml | 4.78 ml |
5 mM | 0.096 ml | 0.478 ml | 0.956 ml |
biological activity | (RS)-MCPG (alpha-MCPG) it is a competitive and selective group I/II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks TBS-induced conversion of hippocampal neurons in young and neonatal rats. |
Target | group I/group II mGluR |