14653-77-1
Amifostine Thiol Dihydrochloride
CAS: 14653-77-1
Molecular Formula: C5H16Cl2N2S
14653-77-1 - Names and Identifiers
14653-77-1 - Physico-chemical Properties
| Molecular Formula | C5H16Cl2N2S |
| Molar Mass | 207.16 |
| Melting Point | 184-186°C |
| Water Solubility | H2O: ≥20mg/mL |
| Appearance | Morphological powder color white to off-white |
| Storage Condition | -20°C |
| Use | WR-1065 dihydrochloride can protect normal tissues from the toxic effects of some cancer drugs and activate p53 through the JNK-dependent signaling pathway. |
14653-77-1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S41 - In case of fire and / or explosion do not breathe fumes. |
| WGK Germany | 3 |
| HS Code | 2930909165 |
14653-77-1 - Introduction
Target
p53
In vitro studies
The DNA-binding activity is increased in a WR-1065 dihydrochloride (WR-1065) concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h reveal that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1, and a 5-fold increase when this reporter gene is driven by NF-κ B, when these values are normalized to the level of the cotransfected β-galactosidase gene.
In vivo studies
The results show that wR-1065 dihydrochloride (WR-1065) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that WR-1065 dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats.
Last Update：2024-04-10 22:29:15
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Multiple SpecificationsSpot supply
Product Name: WR-1065 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 14653-77-1
Tel: 609-228-6898
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Mobile: 609-228-6898
Spot supply
Product Name: Amifostine thiol dihydrochloride Visit Supplier Webpage Request for quotationCAS: 14653-77-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: WR-1065 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 14653-77-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Amifostine Thiol Dihydrochloride Visit Supplier Webpage Request for quotation
CAS: 14653-77-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 14653-77-1
Tel: 18301782025
Email: 3008007409@qq.com
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14653-77-1
化合物 T24363
Remazol Brilliant Violet 8
檸康酐
环戊烷羧酸
乙基二氯化膦
Ethyl n-hexyl carbinol
1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride
顺铂USP24
N-Acetylpiperazine-d4
化合物 T24363
Remazol Brilliant Violet 8
檸康酐
环戊烷羧酸
乙基二氯化膦
Ethyl n-hexyl carbinol
1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride
顺铂USP24
N-Acetylpiperazine-d4