Name | Sulfapyridine |
Synonyms | THAP11 CTG-B43a CTG-B45d HRIHFB2206 Sulfapyridine Sulfapyridine (Dagenan) Sulfapyridine Solution, 100ppm Monoclonal Anti-THAP11 antibody produced in mouse 2-(4-Aminobenzenesulfonamido)pyridineN'-2-Pyridylsulfanilide2-Sulfanilamidopyridine |
CAS | 144-83-2 |
EINECS | 205-642-7 |
InChI | InChI=1/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14) |
Molecular Formula | C11H11N3O2S |
Molar Mass | 249.29 |
Density | 1.3220 (rough estimate) |
Melting Point | 191-193°C |
Boling Point | 473.5±51.0 °C(Predicted) |
Flash Point | 240.2°C |
Solubility | Slightly soluble in water. |
Vapor Presure | 3.9E-09mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Merck | 14,8938 |
BRN | 222065 |
pKa | pKa 8.48(H2Ot = 25I = 0.05) (Uncertain) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Stability | Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents. |
Refractive Index | 1.6740 (estimate) |
MDL | MFCD00038036 |
Physical and Chemical Properties | Yellow-brown to white powder. Melting point 191-193 °c. Slightly soluble in water. |
In vitro study | Sulfapyridine inhibits production of IL-8, chemokine (C-X-C motif) ligand 1 (CXCL1), and monocyte chemotactic protein-1 (MCP-1) in synovial cells of rheumatoid arthritis (RA). MIC range of Sulfapyridine for Y. enterocolitica is 3.1-25 μg/mL and for Salmonella 25-100 μg/mL. Campylobacter jejuni/coli are less susceptible to Sulfapyridine with MIC values ranging from 200 to 800 μg/mL. Shigella and three of five E. coli strains are resistant to 1600 μg/mL of sulfapyridine. Two strains of E. coli are inhibited by 25 μg/mL. |
In vivo study | Sulfapyridine (1 and 10 μg/kg; i.p.) significantly inhibits systemic allergic reaction induced by compound 48/80 in rats. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 2 |
RTECS | DA9625000 |
HS Code | 29350010 |
Hazard Class | IRRITANT |
Toxicity | LD50 orally in mice: 7.5 mg/g (Wien) |
Reference Show more | 1. [IF=7.46] Zijun Xu et al."Machine learning assisted dual-emission fluorescence/colorimetric sensor array detection of multiple antibiotics under stepwise prediction strategy."Sensor Actuat B-Chem. 2022 May;359:131590 |