Molecular Formula | C35H49F2N7O4 |
Molar Mass | 669.8 |
Density | 1.26±0.1 g/cm3(Predicted) |
pKa | 12.90±0.20(Predicted) |
Storage Condition | -20℃ |
In vitro study | MM-102, as a mimetic peptide of MLL1, exhibited high affinity with WDR5, corresponding to an IC50 and Ki of 2.9nM and <1nM, respectively. In MLL1-AF9 of the transfected murine cells, the expression of two important MLL1 target genes (MM-102), which are required for mll1-mediated leukemia formation, was specifically reduced by HoxA9andMeis-1. In addition, MM-102 efficiently and selectively inhibited the growth of leukemia cells containing the MLL1 fusion protein and induced apoptosis of these cells. MM-102, as a mimetic peptide of MLL1, exhibited high affinity to WDR5, corresponding to an IC50 and K I of 2.9nM and <1nM, respectively. In MLL1-AF9 of the transfected murine cells, the expression of two important MLL1 target genes (MM-102), which are required for mll1-mediated leukemia formation, was specifically reduced by HoxA9andMeis-1. In addition, MM-102 efficiently and selectively inhibited the growth of leukemia cells containing the MLL1 fusion protein and induced apoptosis of these cells. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.493 ml | 7.465 ml | 14.93 ml |
5 mM | 0.299 ml | 1.493 ml | 2.986 ml |
10 mM | 0.149 ml | 0.746 ml | 1.493 ml |
5 mM | 0.03 ml | 0.149 ml | 0.299 ml |