1370287-43-6 - Names and Identifiers
1370287-43-6 - Physico-chemical Properties
Molecular Formula | C10H10BrN3O2
|
Molar Mass | 284.11 |
Density | 1.65 |
pKa | -1.78±0.40(Predicted) |
Storage Condition | Room Temprature |
Sensitive | IRRITANT |
MDL | MFCD22377539 |
1370287-43-6 - Introduction
Ethyl-[1,5-a]pyrimidine-6-carboxylate is an organic compound with the chemical formula C10H9BrN4O2.
The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless or light yellow crystal
-Melting point: about 120-122 degrees Celsius
-Solubility: Soluble in some organic solvents, such as chloroform, dichloromethane and dimethylformamide
Use:
- Ethyl-[1,5-a]pyrimidine-6-carboxylate is often used in organic synthesis reactions as a starting material or reagent.
-This compound is often used to synthesize new potential drug molecules or biologically active compounds.
Preparation Method:
Ethyl-[1,5-a]pyrimidine-6-carboxylate can usually be synthesized by the following steps:
1.3-bromopyrazole is reacted with dimethylformamide in the presence of HgCl2 to generate 3-bromopyrazole-2-carboxamide.
2.3-bromopyrazole-2-carboxamide is reacted with methyl ethyl ester in the presence of sodium hydroxide to generate 3-bromo -7-methyl pyrazole-2-carboxamide.
3. finally, 3-bromo-7-methyl pyrazole -2-carboxamide undergoes basic hydrolysis and esterification to generate Ethyl-[1,5-a]pyrimidine-6-carboxylate.
Safety Information:
- Ethyl-[1,5-a]pyrimidine-6-carboxylate is an organic compound, which should be handled safely.
-Use with appropriate protective equipment, such as lab gloves, goggles and lab coats.
-Avoid inhalation, ingestion or contact with skin and eyes.
-During operation, ensure good ventilation conditions.
-This compound may be harmful to the environment and waste must be disposed of properly.
Last Update:2024-04-09 21:00:56