Molecular Formula | C21H19F2N5O |
Molar Mass | 395.41 |
Density | 1.364±0.06 g/cm3(Predicted) |
Solubility | Soluble in DMSO (>25 mg/ml) |
Appearance | Form solid, color Pale yellow |
Color | Pale yellow |
pKa | 13?+-.0.40(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Physical and Chemical Properties | Bioactive PLX5622 is a highly selective CSF-1R inhibitor with IC50 less than 10 nM, and its selectivity for CSF-1R is more than 20 times higher than that of KIT and FLT3. |
Use | The application PLX5622 is a highly selective, effective oral CSF1R inhibitor that can penetrate the blood-brain barrier with a Ki value of 5.9 nM, which can be used for the elimination of expanded and specific microglia before and during the development of the disease course. PLX5622 has good pharmacological properties. |
In vivo study | In mice, rats, dogs, and monkeys, PLX5622 has ideal pharmacokinetic properties with brain permeability of about 20%. PLX5622 had low systemic clearance, moderate volume of distribution, and good oral bioavailability (>30%). It is an effective tool to study the dynamics of microglia. PLX5622 can cause the elimination of persistent, specific microglial cells during or prior to the development of Alzheimer's disease pathology. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.529 ml | 12.645 ml | 25.29 ml |
5 mM | 0.506 ml | 2.529 ml | 5.058 ml |
10 mM | 0.253 ml | 1.265 ml | 2.529 ml |
5 mM | 0.051 ml | 0.253 ml | 0.506 ml |
Solubility | Soluble in DMSO (>25 mg/ml) |