Molecular Formula | C27H31FN6OS |
Molar Mass | 506.64 |
Density | 1.372±0.06 g/cm3(Predicted) |
Solubility | DMSO |
pKa | 14.80±0.30(Predicted) |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
In vitro study | PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ. |
In vivo study | In mouse model, PI-3065 (75 mg/kg, p.o.) also suppresses 4T1 tumor growth and metastasis via inactivation of p110δ. In the LSL.KrasG12D/+; p53R172H/+; PdxCretg/+ (or KPC) model of pancreatic ductal adenocarcinoma, PI-3065 prolongs survival and reduces the incidence of macroscopic metastases and other disease-associated pathologies. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.974 ml | 9.869 ml | 19.738 ml |
5 mM | 0.395 ml | 1.974 ml | 3.948 ml |
10 mM | 0.197 ml | 0.987 ml | 1.974 ml |
5 mM | 0.039 ml | 0.197 ml | 0.395 ml |