1261950-34-8
3',5'-Difluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid
CAS: 1261950-34-8
Molecular Formula: C14H7F5O2
1261950-34-8 - Names and Identifiers
| Name | 3',5'-Difluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid |
| Synonyms | 3-(3,5-Difluorophenyl)-5-trifluoroMethylbenzoic acid 3',5'-Difluoro-5-(trifluoroMethyl)-[1,1'-biphenyl]-3-carboxylic acid 3',5'-Difluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid 1,1'-Biphenyl]-3-carboxylic acid, 3',5'-difluoro-5-(trifluoromethyl)- |
| CAS | 1261950-34-8 |
1261950-34-8 - Physico-chemical Properties
| Molecular Formula | C14H7F5O2 |
| Molar Mass | 302.2 |
| Storage Condition | 2-8℃ |
| Sensitive | IRRITANT |
| MDL | MFCD18320000 |
1261950-34-8 - Introduction
3 ',5'-Difluoro-5-(trifluoromethyl)-[1,1 '-biphenyl]-3-carboxylic acid, also known as 3',5 '-difluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid, is an organic compound. Its chemical structure contains a benzene ring and phenyl respectively attached to three fluorine atoms and a trifluoromethyl group.
The properties of this compound are as follows:
-Appearance: colorless crystal
-melting point: about 145-147 ℃
-Solubility: can be dissolved in organic solvents, such as ether, dimethylformamide, etc., and low solubility in water.
The main use of this compound is as an organic synthesis intermediate. It can be used to synthesize other organic drugs, pesticides, functional materials and other compounds.
The method of preparing 3 ',5'-Difluoro-5-(trifluoromethyl)-[1,1 '-biphenyl]-3-carboxylic acid can be carried out by the following steps:
1. In an appropriate solvent, benzoic acid and trifluoromethylbenzoic acid are esterified to obtain the corresponding esterified product.
2. The esterification product reacts with hydrofluoric acid and ammonium hydrogen fluoride to make it react with alkylation and fluorination.
3. further oxidation reaction is carried out under acidic conditions to make it undergo carboxylation reaction, so as to obtain the final product 3 ',5'-Difluoro-5-(trifluoromethyl)-[1,1 '-biphenyl]-3-carboxylic acid.
Regarding safety information, no detailed studies have been reported on the specific toxicity and harmfulness of this compound. However, as an organic compound, its use and handling should follow the relevant laboratory safety regulations and operating procedures. During handling, it is recommended to wear appropriate personal protective equipment, such as gloves, goggles and protective clothing, to avoid direct contact with the skin and inhalation of its vapors. In addition, it needs to be stored in a dry, well-ventilated place, and stored separately from flammable and explosive materials.
The properties of this compound are as follows:
-Appearance: colorless crystal
-melting point: about 145-147 ℃
-Solubility: can be dissolved in organic solvents, such as ether, dimethylformamide, etc., and low solubility in water.
The main use of this compound is as an organic synthesis intermediate. It can be used to synthesize other organic drugs, pesticides, functional materials and other compounds.
The method of preparing 3 ',5'-Difluoro-5-(trifluoromethyl)-[1,1 '-biphenyl]-3-carboxylic acid can be carried out by the following steps:
1. In an appropriate solvent, benzoic acid and trifluoromethylbenzoic acid are esterified to obtain the corresponding esterified product.
2. The esterification product reacts with hydrofluoric acid and ammonium hydrogen fluoride to make it react with alkylation and fluorination.
3. further oxidation reaction is carried out under acidic conditions to make it undergo carboxylation reaction, so as to obtain the final product 3 ',5'-Difluoro-5-(trifluoromethyl)-[1,1 '-biphenyl]-3-carboxylic acid.
Regarding safety information, no detailed studies have been reported on the specific toxicity and harmfulness of this compound. However, as an organic compound, its use and handling should follow the relevant laboratory safety regulations and operating procedures. During handling, it is recommended to wear appropriate personal protective equipment, such as gloves, goggles and protective clothing, to avoid direct contact with the skin and inhalation of its vapors. In addition, it needs to be stored in a dry, well-ventilated place, and stored separately from flammable and explosive materials.
Last Update：2024-04-09 20:45:29
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