1235865-75-4

1235865-75-4 - Names and Identifiers

Name	Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate
Synonyms	abt199 int 2 ABT199 intermediates ABT-199 Intermediate ABT199 intermediate 3 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate methyl 4-fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate Methyl 2-((1H-pyrrolo[2,3-b]pyrin- 5-yl)oxy)-4-fluorobenzoate methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate Methyl-2-((1H-pyrrolo[2,3-b]pyridine-5-yl)oxy)-4-fluorobenzoate
CAS	1235865-75-4

1235865-75-4 - Physico-chemical Properties

Molecular Formula	C17H23FN2O4
Molar Mass	338.3739232
Density	1.377±0.06 g/cm3(Predicted)
Boling Point	456.9±45.0 °C
pKa	13.21±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Use	This product is an intermediate of ABT 199. ABT 199 is an effective selective BCL-2 inhibitor, which has strong anti-tumor activity while retaining platelets. Its practical application is to treat chronic lymphocytic leukemia cells and estrogen receptor positive breast cancer.

1235865-75-4 - Upstream Downstream Industry

Downstream Products

Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate
2-[(1H-pyrrolo[2,3-B]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl ring Hex-1-enyl]methyl]piperazin-1-yl]benzoic acid

1235865-75-4 - Introduction

Open Data Unverified Data

ABT-199 (Venetoclax), unlike common cancer drugs, is a new type of drug that treats cancer by attacking an important protein called BCL-2. BCL-2 is one of the earliest discovered members of the cell death regulatory BCL-2 protein family. It is associated with many types of cancer, as well as some mental and autoimmune diseases. In cancer, it is thought to act as a suppressor that can help cancer cells resist cancer treatment drugs.

Last Update：2022-06-27 18:40:46