Name | FLLL-32 |
Synonyms | FLLL32 CS-1778 FLLL 32 FLLL-32 EX-A1096 (2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-diMethoxyphenyl)-2-Propen-1-one (2E,2'E)-1,1'-(cyclohexane-1,1-diyl)bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one) (2E,2'E)-1,1'-(cyclohexane-1,1-diyl)bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one) FLLL32 |
CAS | 1226895-15-3 |
Molecular Formula | C28H32O6 |
Molar Mass | 464.55008 |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
In vitro study | FLLL32 down-regulates STAT3 phosphorylation and DNA binding activity in MDA-MB-231 breast cancer and PANC-1 pancreatic cancer cells. FLLL32 inhibited colony formation and cell invasion in MDA-MB-231 cells. For human multiple myeloma, glioblastoma, hepatoma, and colorectal cancer, FLLL32 also results in inhibition of cell proliferation and induction of caspase-3 and PARP cleavage. |
In vivo study | FLLL32 (50 mg/kg, I. p.) significantly reduced tumor burden in MDA-MB-231 xenografted mice. FLLL32 (50 mg/kg, I. p.) also inhibited tumor growth by targeting STAT3 in OS-33 osteosarcoma cell xenografted mice. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.153 ml | 10.763 ml | 21.526 ml |
5 mM | 0.431 ml | 2.153 ml | 4.305 ml |
10 mM | 0.215 ml | 1.076 ml | 2.153 ml |
5 mM | 0.043 ml | 0.215 ml | 0.431 ml |