1224724-39-3

1224724-39-3 - Names and Identifiers

Name	1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester
Synonyms	Methyl 4-Bromoindole-7-carboxylate Methyl 4-broMo-1H-indole-7-carboxylate 1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester
CAS	1224724-39-3

1224724-39-3 - Physico-chemical Properties

Molecular Formula	C10H8BrNO2
Molar Mass	254.08
Density	1.629±0.06 g/cm3(Predicted)
Boling Point	402.3±25.0 °C(Predicted)
pKa	14.49±0.30(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Use	Use 4-bromo-1h-indole-7-carboxylic acid methyl ester can be used as a pharmaceutical synthesis intermediate, the intermediate 4-bromo-2-nitrobenzoic acid methyl ester can be prepared from 4-bromo-2-nitrobenzoic acid as a reaction raw material and further reacted with vinyl magnesium bromide.

1224724-39-3 - Upstream Downstream Industry

Raw Materials

4-Bromo-2-nitrobenzoic acid
1H-Indole-7-carboxylic acid, 4-broMo-
METHYL 4-BROMO-2-NITROBENZOATE
Iodomethane
Vinylmagnesium bromide

1224724-39-3 - Introduction

1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester is an organic compound with the chemical formula C11H9BrNO2. It is a solid with the appearance of white or yellowish crystals.

Nature:
-Melting point: About 90-95 degrees Celsius
-Boiling point: About 355 degrees Celsius
-Density: approx. 1.4g/cm³
-Insoluble in water, but can be dissolved in organic solvents such as ethanol and dichloromethane.

Use:
1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester is often used as an important intermediate and reagent in organic synthesis. It can be used to synthesize pesticides, pharmaceuticals, and other organic compounds. Because it can easily undergo substitution reactions, it is often used to introduce various functional groups.

Preparation Method:
The synthesis of 1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester is mainly carried out by the following reactions:
First, indole is reacted with bromoacetic acid to obtain 4-bromo-lh-indole-7-acetic acid. Then, the final 1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester product was obtained by esterification with methanol and acid catalyst.

Safety Information:
1H-Indole-7-carboxylic acid, 4-broMo-, Methyl ester should be operated in a well-ventilated place and should avoid inhalation, contact with skin or eating. Wear appropriate protective equipment such as goggles and gloves during operation. If you accidentally come into contact with skin or eyes, rinse immediately with plenty of water and seek medical help. This compound may also be flammable and should be kept away from fire and high temperature environments. Safety in handling and storage and disposal of waste in accordance with local regulations.

Last Update：2024-04-09 21:04:16