1204745-88-9 - Names and Identifiers
1204745-88-9 - Physico-chemical Properties
Molecular Formula | C8H5BF6O2
|
Molar Mass | 257.93 |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Irritant |
MDL | MFCD11617946 |
1204745-88-9 - Introduction
3,4-Bis(trifluoromethyl)phenylboronic acid is an organic compound with the formula C10H6BF6O2.
Nature:
-Appearance: Colorless crystalline solid
-melting point: 159-161 ℃
-Solubility: Soluble in common organic solvents such as ether, dichloromethane and chloroform
Use:
- 3,4-Bis(trifluoromethyl)phenylboronic acid is an important organic synthesis intermediate, which is widely used in organic synthesis reactions.
-It can be used to construct C- C and C- N bonds, catalyze asymmetric reactions, synthesize heterocyclic compounds, etc.
Preparation Method:
- 3,4-Bis(trifluoromethyl)phenylboronic acid can be synthesized in three steps.
-First, react 3,4-dibromomethylbenzene with a certain amount of phenylboronic acid to obtain 3,4-bis(trifluoromethyl)benzene.
-Then, the 3,4-Bis(trifluoromethyl)benzene is reacted with trifluoromethanesulfonic acid and sodium hydroxide to obtain 3,4-Bis(trifluoromethyl)phenylboronic acid.
Safety Information:
- 3,4-Bis(trifluoromethyl)phenylboronic acid is generally considered safe, but the following matters still need to be paid attention:
-Wear appropriate personal protective equipment, such as lab gloves and goggles, during operation.
-Avoid contact with skin and inhalation of dust to avoid allergic reactions or irritation.
-Storage should be placed in a dry, cool place, and away from combustibles and oxidants.
-If ingested or inhaled, seek medical attention immediately.
Last Update:2024-04-10 22:29:15