Name | hDHODH-IN-1 |
Synonyms | hDHODH-IN-1 (2z)-N-(biphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 2-Butenamide, N-[1,1'-biphenyl]-4-yl-2-cyano-3-hydroxy- |
CAS | 1173715-42-8 |
Molecular Formula | C17H14N2O2 |
Molar Mass | 278.31 |
Density | 1.256±0.06 g/cm3(Predicted) |
Melting Point | 270-275 °C (decomp) |
Boling Point | 514.6±50.0 °C(Predicted) |
Appearance | Solid |
pKa | 5.20±0.50(Predicted) |
Storage Condition | 2-8°C,密封,干燥 |
In vitro study | Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because DHODH is required to ensure proliferating-cell viability, inhibitors have been developed to eliminate human DHODH (hDHODH) activity, which is associated with cancers, multiple sclerosis, and autoimmune and inflammatory diseases. |
biological activity | hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory effects. |