Molecular Formula | C25H19N3O3 |
Molar Mass | 409.44 |
Density | 1.425±0.06 g/cm3(Predicted) |
Boling Point | 643.9±55.0 °C(Predicted) |
Specific Rotation(α) | -3.0~+3.0°(20℃/D)(c=0.1,CH3CN) |
Solubility | Soluble in DMSO |
Appearance | Liquid |
Color | white to beige |
pKa | 11.88±0.43(Predicted) |
Storage Condition | room temp |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Use | IWR-1 are end-anchor polymerase inhibitors that inhibit the Wnt/β-catenin signaling pathway. |
In vitro study | IWR-1 and XAV939, as reversible inhibitors of the Wnt pathway, have similar pharmacological effects in vitro and in vivo, with IWR-1 acting through interaction with Axin, while XAV939 binds directly to TNKS. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.442 ml | 12.212 ml | 24.424 ml |
5 mM | 0.488 ml | 2.442 ml | 4.885 ml |
10 mM | 0.244 ml | 1.221 ml | 2.442 ml |
5 mM | 0.049 ml | 0.244 ml | 0.488 ml |