1025015-40-0
GK921
CAS: 1025015-40-0
Molecular Formula: C21H20N4O
1025015-40-0 - Names and Identifiers
1025015-40-0 - Physico-chemical Properties
| Molecular Formula | C21H20N4O |
| Molar Mass | 344.41 |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | GK921 inhibits the TGase 2-induced polymerization of I-κBα and p53 in a dose-dependent manner. The cytotoxicity of GK921 ranged from GI 50 of 10 -10 to 10 -4 M. The average GI 50 is 9.05×10 -7 M. GK921 rescues p53 levels and consequently induces apoptosis; a concentration-dependent increase in cleaved poly(ADP-ribose) polymerase (c-PARP) and p53 levels is observed. |
| In vivo study | A single treatment with GK921 almost completely reduces tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. |
1025015-40-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.904 ml | 14.518 ml | 29.035 ml |
| 5 mM | 0.581 ml | 2.904 ml | 5.807 ml |
| 10 mM | 0.29 ml | 1.452 ml | 2.904 ml |
| 5 mM | 0.058 ml | 0.29 ml | 0.581 ml |
Last Update：2024-01-02 23:10:35
1025015-40-0 - Reference Information
| biological activity | GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μm. |
| Target | Value |
| TGase 2 () | 8.93 μM |
Last Update：2024-04-09 22:18:34
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Mobile: +86-18621343501
QQ: 2881950922
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View History
1025015-40-0
2-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLETHANAMINE HYDROCHLORIDE
β-苯基丙烯酰氯
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2-(1-哌嗪基)-3-吡啶羧酸甲酯盐酸盐
BENZYL 7-CHLORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE
(S)-6,6'-dichloro-2,2'-diethoxy-1,1'-binaphthylene-4,4'-dicarboxylic acid
1,3-双(2,6-二异丙基苯基)咪唑鎓氯盐
2-AMINO-3-BROMO-9-FLUORENONE
5-氯噻唑-2-甲酸甲酯
2-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLETHANAMINE HYDROCHLORIDE
β-苯基丙烯酰氯
(4-bromophenyl)acetonitrile
2-(1-哌嗪基)-3-吡啶羧酸甲酯盐酸盐
BENZYL 7-CHLORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE
(S)-6,6'-dichloro-2,2'-diethoxy-1,1'-binaphthylene-4,4'-dicarboxylic acid
1,3-双(2,6-二异丙基苯基)咪唑鎓氯盐
2-AMINO-3-BROMO-9-FLUORENONE
5-氯噻唑-2-甲酸甲酯