100490-36-6
TOSUFLOXACIN TOSILATE
CAS: 100490-36-6
Molecular Formula: C19H15F3N4O3
100490-36-6 - Names and Identifiers
100490-36-6 - Physico-chemical Properties
| Molecular Formula | C19H15F3N4O3 |
| Molar Mass | 404.34 |
| Density | 1.558±0.06 g/cm3(Predicted) |
| Boling Point | 614.4±55.0 °C(Predicted) |
| pKa | 5.79±0.70(Predicted) |
| Physical and Chemical Properties | Chemical properties colorless needle crystal, melting point 266~268 ℃. |
| Use | The use has broad-spectrum antibacterial activity. It has strong antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, epiporum, suppuration and Streptococcus pneumoniae, and has strong antibacterial activity against Gram-negative bacteria including Pseudomonas aeruginosa and anaerobic bacteria. Strong antibacterial activity and bactericidal effect. Used for respiratory tract infection, soft tissue injury, pneumonia, urinary tract infection, gynecological infection, oral and otolaryngological infection. |
100490-36-6 - Upstream Downstream Industry
| Raw Materials | p-Toluenesulfonic acid Glycine Pyrrolidine 2,4-Difluoroaniline 2-Chloropyridine-N-oxide Ethyl fluoroacetate 3-Aminopyrrolidine Tosufloxacin |
100490-36-6 - Production method
The process using orthopyridine as raw material is as follows.
In addition, 2, 6-dichloro-5-fluoro-3-acetylchloropyridine is used as the raw material, and diethyl malonate is reacted to form malonic acid derivatives, and then hydrolyzed and decarboxylated to form acetic acid derivatives, and then first with the original Methyl triethyl ester, then react with 2, 4-difluoroaniline, and then cyclize to form naphthalene derivatives, react with 3-aminotetrahydropyrrole to form polyfluorinated acid, and finally with p-toluene sulfonic acid in aqueous ethanol Salt, tofloxacin was obtained.
Its main intermediate 2, 6-dichloro-5-fluoro-3-acetylchloropyridine can be formed by the following reaction with ethyl fluoroacetate as raw material.
Another intermediate, 3-aminotetrahydropyrrole, can be prepared from glycine.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: A-61827 Visit Supplier Webpage Request for quotationCAS: 100490-36-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Tosufloxacin Visit Supplier Webpage Request for quotationCAS: 100490-36-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: TOSUFLOXACIN TOSILATE Visit Supplier Webpage Request for quotation
CAS: 100490-36-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 100490-36-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: A-61827 Visit Supplier Webpage Request for quotationCAS: 100490-36-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Tosufloxacin Visit Supplier Webpage Request for quotationCAS: 100490-36-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: TOSUFLOXACIN TOSILATE Visit Supplier Webpage Request for quotation
CAS: 100490-36-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 100490-36-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
100490-36-6
N-cyclohexyl-N-ethyl-2,5-dimethoxybenzenesulfonamide
2226034-40-6
Bis[1,3-bis(trimethylsilyl)cyclopentadienyl]zirconium dichloride
3-Pyridazineethanol
802002-40-0
23144-40-3
(S)-2-Amino-6-(((3-(3-methyl-3H-diazirin-3-yl)propoxy)carbonyl)amino)hexanoic acid
5-Bromo-1-ethyl-3-nitro-1,2-dihydropyridin-2-one
2,3,4,5-Tetrahydro-1H-benzo[b]azepin-5-amine hydrochloride
N-cyclohexyl-N-ethyl-2,5-dimethoxybenzenesulfonamide
2226034-40-6
Bis[1,3-bis(trimethylsilyl)cyclopentadienyl]zirconium dichloride
3-Pyridazineethanol
802002-40-0
23144-40-3
(S)-2-Amino-6-(((3-(3-methyl-3H-diazirin-3-yl)propoxy)carbonyl)amino)hexanoic acid
5-Bromo-1-ethyl-3-nitro-1,2-dihydropyridin-2-one
2,3,4,5-Tetrahydro-1H-benzo[b]azepin-5-amine hydrochloride
Raw Materials for 100490-36-6