1-苯酰基-4-哌啶酮
N-Benzoyl-4-piperidone
CAS: 24686-78-0
Molecular Formula: C12H13NO2
1-苯酰基-4-哌啶酮 - Names and Identifiers
| Name | N-Benzoyl-4-piperidone |
| Synonyms | N-BENZOYLPIPERIDONE N-BENZOYL-4-PIPERIDONE N-Benzoyl-4-piperidone 1-Benzoyl-piperidinoine 1-benzoylpiperidin-4-one 4-Piperidone, 1-benzoyl- 1-Benzoyl-4-piperidinone 1-Benzoyl-4-oxopiperidine 1-BENZOYL-PIPERIDIN-4-ONE 4-Piperidinone,1-benzoyl- |
| CAS | 24686-78-0 |
| EINECS | 246-407-9 |
| InChI | InChI=1/C12H13NO2/c14-11-6-8-13(9-7-11)12(15)10-4-2-1-3-5-10/h1-5H,6-9H2 |
1-苯酰基-4-哌啶酮 - Physico-chemical Properties
| Molecular Formula | C12H13NO2 |
| Molar Mass | 203.24 |
| Density | 1.1255 (rough estimate) |
| Melting Point | 55-59 °C (lit.) |
| Boling Point | 158-160 °C/0.2 mmHg (lit.) |
| Flash Point | >230°F |
| Solubility | methylene chloride: soluble |
| Vapor Presure | 9.9E-07mmHg at 25°C |
| Appearance | Solid |
| Color | White to Light yellow |
| BRN | 158848 |
| pKa | -1.45±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5440 (estimate) |
| MDL | MFCD00006189 |
1-苯酰基-4-哌啶酮 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29333999 |
| Hazard Note | Irritant |
1-苯酰基-4-哌啶酮 - Reference Information
| Use | 1-benzoyl-4-piperidone is an organic intermediate that can be used to prepare perpiperazine. Perpiperazine and its derivatives are important pharmaceutical intermediates and fine chemical raw materials with a wide range of applications. |
| preparation | 4-piperidone hydrochloride hydrate (7.68kg) and potassium carbonate (20.7kg) are added with water (50 liters) at 0 ℃, after stirring evenly, dichloromethane (40 liters) is added, and then methoxycarbonyl succinimide (12.4kg) dichloromethane (80 liters) solution is added dropwise, reaction at room temperature for two hours. The reaction liquid is separated, the water layer is extracted with dichloromethane (2 × 15 liters), the organic phase is combined, and the anhydrous sodium sulfate is dried and concentrated to obtain 11.5kg of colorless oily 1-benzoyl-4-piperidone. |
Last Update：2024-04-10 22:41:03
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View History
1-苯酰基-4-哌啶酮
N-(6-氰基-2-吡啶基)乙酰胺
异丁基氯化镁 2M THF
C.I. Reactive Yellow 160
阿戈美拉汀杂质 二胺
3-甲酯基-2-吡喃酮
3-羟基-2-苯乙胺盐酸盐
2'-Hydroxy-3',5'-dimethylacetophenone
4-CHLOROBENZYL 2-HYDROXYETHYL SULPHIDE
3-(3-CHLORO-ISOXAZOL-5-YL)-PROPIONIC ACID
N-(6-氰基-2-吡啶基)乙酰胺
异丁基氯化镁 2M THF
C.I. Reactive Yellow 160
阿戈美拉汀杂质 二胺
3-甲酯基-2-吡喃酮
3-羟基-2-苯乙胺盐酸盐
2'-Hydroxy-3',5'-dimethylacetophenone
4-CHLOROBENZYL 2-HYDROXYETHYL SULPHIDE
3-(3-CHLORO-ISOXAZOL-5-YL)-PROPIONIC ACID