1-phenyl-propan-1-one
Propiophenone
CAS: 93-55-0
Molecular Formula: C9H10O
1-phenyl-propan-1-one - Names and Identifiers
| Name | Propiophenone |
| Synonyms | FEMA 3469 usafek-1235 USAF ek-1235 phenylpropone Propiophenone Propionphenone 1-phenylpropanone AKOS BBS-00003274 lithylphenyllwton ketone,ethylphenyl αthylenphenylketon 1-phenyl-1-propanon 1-phenylpropanone-1 Ethyl phenyl ketone Ketone, ethyl phenyl 1-Phenyl-1-propanone 1-Propanone,1-phenyl- 1-phenyl-propan-1-one |
| CAS | 93-55-0 |
| EINECS | 202-257-6 |
| InChI | InChI=1/C9H10O/c1-2-9(10)8-6-4-3-5-7-8/h3-7H,2H2,1H3 |
| InChIKey | KRIOVPPHQSLHCZ-UHFFFAOYSA-N |
1-phenyl-propan-1-one - Physico-chemical Properties
| Molecular Formula | C9H10O |
| Molar Mass | 134.18 |
| Density | 1.009g/mLat 25°C(lit.) |
| Melting Point | 17-19°C(lit.) |
| Boling Point | 218°C(lit.) |
| Flash Point | 190°F |
| JECFA Number | 824 |
| Water Solubility | INSOLUBLE |
| Solubility | Difficult to mix. |
| Vapor Presure | 1 mm Hg ( 50 °C) |
| Appearance | Liquid |
| Color | Clear colorless to light yellow |
| Merck | 14,7830 |
| BRN | 606215 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Refractive Index | n20/D 1.526(lit.) |
| Physical and Chemical Properties | Density 1.009 melting point 18°C boiling point 218°C refractive index 1.5248-1.5268 flash point 87°C water-soluble INSOLUBLE |
| Use | For general reagents, pharmaceutical, flavor, fragrance and organic synthesis industry |
1-phenyl-propan-1-one - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | UG7175000 |
| TSCA | Yes |
| HS Code | 2914 39 00 |
| Toxicity | LD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg |
1-phenyl-propan-1-one - Nature
Open Data Verified Data
crystalline or colorless liquid, relative density 0105. Melting point 21 °c. Boiling point 218 ℃,92.2 ℃(1. 33kPa). Refractive index 5269. Insoluble in water, ethylene glycol, propylene glycol and glycerol, soluble in alcohol, ether, benzene, toluene, etc.
Last Update：2024-01-02 23:10:35
1-phenyl-propan-1-one - Preparation Method
Open Data Verified Data
prepared by condensation of benzene with propionyl chloride and hydrolysis.
Last Update：2022-01-01 10:42:45
1-phenyl-propan-1-one - Safety
Open Data Verified Data
combustion produces irritant, corrosive and/or toxic gases. Its gas forms an explosive mixture with air. Inhalation, ingestion and skin contact are harmful. Should wear protective glasses, protective clothing, protective gloves.
Last Update：2022-01-01 10:42:45
1-phenyl-propan-1-one - Reference Information
| FEMA | 3469 | PROPIOPHENONE |
| LogP | 2.71 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | GRAS(FEMA). |
| usage limit | FEMA(mg/kg): non-alcoholic beverages 0.2; Cold drinks, candy, baked goods, gels, pudding, 1.0. |
| Use | It is used in organic synthesis, as an intermediate for the drugs medothymol and cholanol, and as a fragrance fixative. used in general reagents, pharmaceuticals, flavors, fragrances and organic synthesis used in the pharmaceutical industry, also used as intermediates in organic synthesis used in general reagents, pharmaceuticals, flavors, fragrance and organic synthesis industry organic synthesis. Fixative. |
| production method | from benzene and propionyl chloride by condensation, hydrolysis. The benzene and anhydrous aluminum trichloride were put into a glass-lined reaction Pan, cooled to 10 ° C. With stirring, and a mixture of propionyl chloride and anhydrous benzene was added dropwise. After dropping, slowly raise the temperature to 20 °c for 1H. The reaction solution was added to ice water, and the mixture was hydrolyzed by stirring at 30 °c or lower. The oil layer was separated by standing, washed with sodium hydroxide solution, washed with water until neutral, and distilled under reduced pressure to collect a 12-120 ° C. (4.0kPa) fraction, I .e., phenylacetone, with a yield of 85%. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:12
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