Molecular Formula | C6H13NO |
Molar Mass | 115.17 |
Density | 0.999 g/mL at 25 °C(lit.) |
Melting Point | 76-78 °C11 mm Hg(lit.) |
Flash Point | 158 °F |
Water Solubility | Fully misicible in water. |
Refractive Index | n20/D 1.475 |
Physical and Chemical Properties | Chemical Properties The boiling point of the product is 76-78 ℃(1.47kPa), the relative density is 0.999, the refractive index is 1.4740, and the flash point is 70 ℃. |
Use | Uses intermediates in organic synthesis. |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R6/37/38 - |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
Raw Materials | Hydrogen bromide Nickel Potassium hydroxide solution |
WGK Germany | 3 |
Hazard Note | Irritant |
TSCA | Yes |
customs code | 29333990 |
furfural is used as raw material, which is obtained by condensation with methylamine, hydrogenation reduction and ring expansion. Mix furfural, methylamine, anhydrous ethanol and Raney nickel, and introduce hydrogen at 85-95 ℃ for about 6 hours. Filter and neutralize with dilute sulfuric acid to pH 6-7. After ethanol is recovered, benzene is used to extract the extract, anhydrous potassium sulfate is added to dry, benzene is recovered and fractionated at atmospheric pressure, and 150-166 ℃ fraction is collected to obtain condensate with 91% yield. The above condensate is mixed with ice aldehyde acid, dry hydrogen bromide gas is introduced at 100-105 ℃, and the ventilation reaction is carried out for 2 hours. Then cool to about 80 ℃, and neutralize with saturated potassium hydroxide solution to pH above 8. Regular pressure distillation and toluene extraction, the extraction solution is distilled under reduced pressure, and the fraction at 74-80 ℃(2.13kPa) is collected to obtain 3-hydroxy-N-methyl piperidine.
acidity coefficient (pKa) | 14.95±0.20(Predicted) |
water solubility | Fully misicible in water. |
BRN | 103017 |
NIST chemical information | 3-Piperidinol, 1-methyl-(3554-74-3) |
EPA chemical information | 3-Piperidinol, 1-methyl- (3554-74-3) |