Name | 4-ISOTHIOCYANATO-4'-NITRODIPHENYL ETHER |
Synonyms | Lopatol nitroscanate cantrodifene p-(p-Nitrophenoxy)phenyl isothiocyanate 4-ISOTHIOCYANATO-4'-NITRODIPHENYL ETHER 1-isothiocyanato-4-(4-nitrophenoxy)-benzen 1-(4-Isothiocyanatophenoxy)-4-nitrobenzene Benzene, 1-isothiocyanato-4-(4-nitrophenoxy)- isothiocyanicacid,p-(p-nitrophenoxy)phenylester |
CAS | 19881-18-6 |
EINECS | 243-393-6 |
Molecular Formula | C13H8N2O3S |
Molar Mass | 272.28 |
Density | 1.3946 (rough estimate) |
Melting Point | 122 °C |
Boling Point | 202°C (rough estimate) |
Storage Condition | 2-8°C |
Refractive Index | 1.6360 (estimate) |
Physical and Chemical Properties | Melting point 107-113 ℃. Soluble in acetone, insoluble in water. |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | 2811 |
Hazard Class | IRRITANT-HARMFUL |
Use | new drug for Taenia. It has a significant effect on the adult and larva of Echinococcus granulosus, and the repellent rate is 92.6%. On nematodes, schistosomiasis also has good efficacy. |
production method | 1-(4-nitrophenoxy) is obtained by condensation of p-nitrochlorobenzene with P-nitrophenol in the presence of potassium hydroxide -4-nitrobenzene is then reduced to 1-(4-aminophenoxy)-4-nitrobenzene with iron powder. Finally, the reaction with sulfur light oxygen or five sulfur two phosphorus, and the preparation of nitrate sulfur cyanide ether. The Intermediate 1-(4-aminophenoxy)-4-nitrobenzene can also be prepared by condensation of p-nitrochlorobenzene with paracetamol. |