Name | Cyclopentyl methyl ketone |
Synonyms | Acetylcyclopentane Cyclopentylethanone CYCLOPENTYLETHANONE 1-Acetylcyclopentane 1-Cyclopentyl-Ethanone 1-CYCLOPENTYL-ETHANONE ethanone, 1-cyclopentyl- 1-cyclopentylethan-1-one Cyclopentyl methyl ketone Cyclopentyl(methyl) ketone |
CAS | 6004-60-0 |
EINECS | 1312995-182-4 |
InChI | InChI=1/C7H12O/c1-6(8)7-4-2-3-5-7/h7H,2-5H2,1H3 |
Molecular Formula | C7H12O |
Molar Mass | 112.17 |
Density | 0.913 |
Boling Point | 151-156℃ |
Flash Point | 47°C |
Water Solubility | Miscible with water. |
Vapor Presure | 2.44mmHg at 25°C |
Appearance | clear liquid |
Color | Colorless to Almost colorless |
Storage Condition | 2-8°C |
Refractive Index | 1.4435 |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
Hazard Class | IRRITANT |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
application | cyclopentanone can be used as an intermediate in organic synthesis and pharmaceutical, mainly used in laboratory research and development and chemical production. |
preparation | in the reaction bottle, add 1, 4-dibromobutane (216g,1.0mol) and the content of 40% sodium hydride (90g, 1.5mol), and slowly heat to 50 ℃ under nitrogen protection; Add methyl acetoacetate (116g,1.0mol) slowly, keep the temperature not more than 55 ℃, after dropping, heat and stir at 50 ℃ for 3 hours. After TLC monitors the reaction of raw materials, adjust the pH of reaction solution to 8~9 with 1N HCl solution, keep the temperature at 60 ℃ for 2 hours, and then cool down to 40 ℃; The organic phase is separated, washed once with 100mL of saturated sodium chloride dissolved solution, dried with 5g of anhydrous magnesium sulfate, and finally concentrated in vacuum to obtain 102g of cyclopentyl ketone, the yield was 91%. |