Molecular Formula | C6H3ClFNO2 |
Molar Mass | 175.54 |
Density | 1.61 |
Melting Point | 40-42°C(lit.) |
Boling Point | 227-232°C |
Flash Point | >230°F |
Solubility | soluble in Methanol |
Vapor Presure | 0.0893mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow to Green |
BRN | 1944997 |
Storage Condition | Sealed in dry,Room Temperature |
Sensitive | Sensitive to air |
Refractive Index | 1.554 |
MDL | MFCD00007206 |
Physical and Chemical Properties | White crystals. The melting point is 44-47 °c, the boiling point is 227-237 °c, and the flash point is> 110 °c. |
Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | 2811 |
WGK Germany | 3 |
RTECS | CZ0720000 |
HS Code | 29049090 |
Hazard Note | Irritant |
Hazard Class | 6.1 |
Packing Group | III |
white crystals. Melting point 44~47 ℃, boiling point 227~237 ℃, flash point> 110 ℃. This product is irritating.
This product can be used for the preparation of 3 chloro -4-fluoroaniline, is the basic raw material for the synthesis of drugs such as quinonic acid.
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | 2-chloro-1-fluoro-4-nitrobenzene, also known as 3-chloro-4-fluoronitrobenzene, is an intermediate of norfloxacin and can also be used to produce 3-chloro-4-fluoroaniline. it is the basic raw material for the synthesis of quinnoic acid and other drugs , and can also be used in pesticide production and other aspects. 3-chloro-4-fluoronitrobenzene can be used to prepare 3-chloro-4-fluoroaniline hydrochloride. 3-chloro-4-fluoroaniline is a very important starting material in the synthesis of anticancer drug gefitinib, and it is also an important intermediate in the synthesis of antibacterial drug norfloxacin. In addition, 3-chloro-4-fluoroaniline is also an important intermediate for the synthesis of fluorine-containing pesticide herbicides, plant growth regulators, fungicides, etc. |
application | 3-chloro-4-fluoronitrobenzene is an important pharmaceutical and pesticide intermediate. if 3-chloro-4-fluoroaniline is reduced, norfloxacin can be prepared; if 2, 4-dichlorofluorobenzene is prepared by chlorination and denitration, ciprofloxacin can be prepared by further synthesis. |
use | intermediate of norfloxacin. It can also be used to make 3-chloro-4-fluoroaniline, which is the basic raw material for the synthesis of quinnoic acid and other drugs. It is an important pharmaceutical and pesticide intermediate. If 3-chloro-4-fluoroaniline is obtained by reduction, norfloxacin can be obtained, and 2,4-dichlorofluorobenzene can be obtained by chlorination and denitration. Ciprofloxacin can be prepared by further synthesis. |
production method | nitration with fluorobenzene with mixed acid to generate p-fluoronitrobenzene, and then chlorination with chlorine to prepare the product. |
category | toxic substances |
flammability hazard characteristics | flammability; fire scene decomposition of toxic nitrogen oxides; fluoride and chloride smoke |
storage and transportation characteristics | warehouse low temperature, ventilation, drying |
fire extinguishing agent | water, carbon dioxide, dry powder, sand |