Molecular Formula | C9H10O3 |
Molar Mass | 166.17 |
Density | 1.129g/mLat 25°C(lit.) |
Boling Point | 122-124°C18mm Hg(lit.) |
Flash Point | >230°F |
Storage Condition | Room Temprature |
Refractive Index | n20/D 1.514(lit.) |
MDL | MFCD00017221 |
WGK Germany | 3 |
Structure and properties | 2-methoxyphenyl acetate, also known as 1-acetoxy-2-methoxybenzene, 1-acetoxy-2-methoxybenzene, O-methoxyphenol acetate, etc. 2-methoxyphenyl acetate is a white to slightly pink-cream crystalline powder at room temperature, with density heavier than water, and 2-methoxyphenyl acetate is stable at room temperature and atmospheric pressure, holding the container sealed, stored in a cool, dry place storage will not decompose, avoid contact with oxidative substances. |
synthesis | methoxyphenylacetic acid such as O-(p-, m-) methylphenylacetic acid, 2-methoxyphenyl acetate is an important intermediate of organic chemical fine chemicals, which is mainly used in the manufacture of pesticides, medicines and corresponding esters. In the prior art, the preparation method of acetic acid -2-methoxy phenyl Ester is not reported, but the synthesis and preparation methods of its analog phenylacetic acid are very many, and the synthesis process route is mainly as follows: (1) Hydrolysis of phenylacetonitrile: first, phenylacetonitrile is generated by chlorhexidine and sodium cyanide in the presence of a solvent, then arylacetonitrile is further reacted, and finally, arylacetic acid is hydrolyzed in dilute sulfuric acid. This method has a high yield in this step of hydrolysis, but a low yield in the synthesis of phenylacetonitrile, and sodium cyanide is highly toxic. (2) phenylacetamide hydrolysis method: Styrene is used as a raw material to generate phenylacetamide by reacting with ammonia water and sulfur, and the reaction is continued to obtain arylacetamide, which is then hydrolyzed to generate arylacetic acid. This method is simple, the operation conditions are easy to control, raw materials and intermediate product toxicity is small, but styrene and ammonia, sulfur this step of the reaction by-product of benzene ethyl mercaptan, The odor is peculiar, the environment is polluted, and the reaction needs to be pressurized, which limits the application of the reaction. (3) carbon-based synthesis method: under the action of a carbon-based catalyst, chloroarylmethane is subjected to a carbon-based alkylation reaction in a two-phase system of sodium hydroxide and an organic solvent at low pressure and temperature, sodium aryl acetate is formed and then acidified to aryl acetic acid. After the esterification reaction, acetic acid -2-methoxyphenyl Ester is obtained. The product of this method has high purity and mild reaction conditions, but there are high technical requirements in the process, careful operation is required to prevent catalyst deactivation or loss, and the yield has yet to be improved. |