Molecular Formula | C17H27NO4 |
Molar Mass | 309.4 |
Density | 1.0449 (rough estimate) |
Melting Point | 125-130°C |
Boling Point | 449.67°C (rough estimate) |
Water Solubility | 8.30g/L(25 ºC) |
Solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone. |
Appearance | neat |
Color | White to Off-White |
pKa | 9.67(at 25℃) |
Storage Condition | Refrigerator |
Refractive Index | 1.5420 (estimate) |
Physical and Chemical Properties | Crystalline powder. Melting point 124-136 ℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone, benzene. |
In vitro study | In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a K i value of 19.4 μM. With respect to Nadolol, the K m for OATP1A2 is 84 μM. |
In vivo study | In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
WGK Germany | 2 |
RTECS | QJ4870000 |
HS Code | 2922190900 |
Toxicity | LD50 in mice, rats (mg/kg): 4500, 5300 orally (Antonaccio, Evans) |
biological activity | Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective β-adrenergic receptor antagonist with antihypertensive and antiarrhythmic activity. |
target | TargetValue β-adrenergic receptor () |
Target | Value |
in vitro study | in human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a k I value of 19.4 μ m. with respect to Nadolol, the k m for OATP1A2 is 84 μ m. |
in vivo study | in male OF1 bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
chemical properties | crystalline powder. Melting point 124-136 ℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone and benzene. |
use | antiarrhythmic drugs. |
production method | cis -5,6,7,8-tetrahydro -1,6,7-naphthol (melting point 188-188.5 ℃) is prepared from 5,8-dihydro -1-naphthol, and then react with sodium methoxide, dimethyl sulfoxide and 3-chloro -1,2-propylene oxide to produce 2,3-cis -1,2,3,4-tetraoxy -5-[2,3-(epoxy) propoxy]-2,3-naphthol diol, and then react with tert-butylamine to obtain naphthalene hydroxy. |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |