Molecular Formula | C8H7NO2S |
Molar Mass | 181.21 |
Density | 1.40±0.1 g/cm3(Predicted) |
Boling Point | 289.4±42.0 °C(Predicted) |
pKa | 10?+-.0.20(Predicted) |
Storage Condition | 2-8°C |
Sensitive | Irritant |
MDL | MFCD00423324 |
Application | 4-methoxybenzo [D] oxazol-2 (3H)-Thione can be used as a pharmaceutical intermediate to synthesize other compounds with certain activity, and its application is rarely reported. Analogs of 4-methoxybenzo [D] oxazol-2 (3H)-thione [5-methoxybenzo [d] oxazol-2 (3h)]-Thione] is a key intermediate impurity of omeprazole, a first generation benzimidazole gastric acid proton pump inhibitor developed by Astra Zen-eca company in Sweden, mainly used for the treatment of peptic gastric ulcer and reflux gastritis. According to the European Pharmacopoeia EP8.0, Omeprazole has 9 known impurities (A ~ I,Chart 1): impurity A is the key intermediate of omeprazole, 5-methoxy-1h-benzo [d] imidazole-2-thiol, and impurity B- I is the process impurity and degradation impurity of Omeprazole. |