1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one
K-Ras(G12C) inhibitor 12
CAS: 1469337-95-8
Molecular Formula: C15H17ClIN3O3
1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one - Names and Identifiers
1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one - Physico-chemical Properties
| Molecular Formula | C15H17ClIN3O3 |
| Molar Mass | 449.67 |
| Density | 1.736±0.06 g/cm3(Predicted) |
| Boling Point | 680.2±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 48 mg/mL |
| pKa | 8.60±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | K-Ras(G12C) inhibitor 12 belongs to a series of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block the K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. K-Ras(G12C) inhibitor 12 belongs to a family of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interactions. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. |
1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.224 ml | 11.119 ml | 22.238 ml |
| 5 mM | 0.445 ml | 2.224 ml | 4.448 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.224 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one - Reference Information
| biological activity | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of carcinogenic K-Ras(G12C). K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of carcinogenic K-Ras(G12C). |
| in vitro study | K-Ras(G12C) inhibitor 12 is a series of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. |
| target | TargetValue K-Ras(G12C) () |
| Target | Value |
Last Update：2024-04-09 21:54:55
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Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
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Mobile: +86-18621343501
QQ: 2881950922
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Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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View History
1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)aMino)acetyl)piperazin-1-yl)prop-2-en-1-one
4-溴-1H-吡咯并[2,3-b]吡啶-2-羧酸
Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
对三氟甲基苯甲脒盐酸盐
2-Propen-1-one, 1-[3-[4-amino-5-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-1-piperidinyl]-
甲磺酸甲酯-D6
TERT-BUTYL 2-OXOPYRROLIDINE-1- CA
5H-Cyclopentapyrazin-6-amine, 6,7-dihydro-
N-[4-tert-Butyl-1-(4-tert-butyl-1-cyclohexenyl)cyclohexyl]hydroxylamine
TH588 (hydrochloride)
4-溴-1H-吡咯并[2,3-b]吡啶-2-羧酸
Imidazo[1,2-a]pyridine-8-carboxaldehyde (9CI)
对三氟甲基苯甲脒盐酸盐
2-Propen-1-one, 1-[3-[4-amino-5-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-1-piperidinyl]-
甲磺酸甲酯-D6
TERT-BUTYL 2-OXOPYRROLIDINE-1- CA
5H-Cyclopentapyrazin-6-amine, 6,7-dihydro-
N-[4-tert-Butyl-1-(4-tert-butyl-1-cyclohexenyl)cyclohexyl]hydroxylamine
TH588 (hydrochloride)