Molecular Formula | C7H6Cl2N2S |
Molar Mass | 221.11 |
Melting Point | 193-194°C |
Boling Point | 317.4℃ |
Appearance | Solid |
BRN | 2212146 |
Storage Condition | Sealed in dry,Room Temperature |
MDL | MFCD00041154 |
Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
UN IDs | 2811 |
RTECS | YS9275000 |
HS Code | 29309090 |
Hazard Class | 6.1 |
Packing Group | III |
Uses | 2,5-dichlorophenyl thiourea is a pharmaceutical intermediate, which can be prepared from 2,5-dichloroaniline in one step. It has been reported that 2, 5-dichlorophenyl thiourea can be used to prepare the bactericidal compound N-(2, 5-dichlorophenyl)-4-(pyridin-2-yl)-5-(1H-1,2, 4-triazol-1-yl) thiazol-2-amine. |
preparation method | take 0.1 moles of 2, 5-dichloroaniline, add 9ml of HCl and 25ml of water, and heat the solution in a round bottom flask at about 60-70 ℃ for about 1 hour. The mixture was cooled for about 1 h and then 0.1 moles of ammonium thiocyanate was slowly added to the solution. The solution is now refluxed for about 4 hours. Add 20ml of water to the solution under constant stirring. The solution was filtered and dried to obtain powdered 2,5-dichlorophenylthiourea. |
application | Zhang mu et al. reported that 2,5-dichlorophenyl thiourea can be used to prepare the following 2-aminothiazole derivative compound 6h N-(2,5-dichlorophenyl)-4-(pyridine -2-yl)-5-(1H-1,2, 4-Triazol-1-yl) thiazol-2-amine. 2-Aminothiazole derivatives not only have good insecticidal, bactericidal, herbicidal and plant growth regulation activities, but also have excellent pharmacological activities. Due to their simple synthesis method and diverse biological activities, they have attracted much attention from pesticide and pharmaceutical developers. |