1-(1-chlorethyl)-2,3-dimethylbenzylidene
1-(2,3-Dimethylphenyl)ethyl chloride
CAS: 60907-88-2
Molecular Formula: C10H13Cl
1-(1-chlorethyl)-2,3-dimethylbenzylidene - Names and Identifiers
| Name | 1-(2,3-Dimethylphenyl)ethyl chloride |
| Synonyms | Medetomidine Impurity 30 3-Dimethylphenyl)ethyl chloride 1-(1-CHLOROETHYL)-2,3-DIMETHYLPHENYL 1-(2,3-Dimethylphenyl)ethyl chloride 1-(2,3-dimethylphenyl)ethyl chloride 1-(1-Chloroethyl)-2,3-dimethylbenzene 1-(1-chloroethyl)-2,3-dimethylbenzene Benzene,1-(1-chloroethyl)-2,3-dimethyl- 1-(1-chlorethyl)-2,3-dimethylbenzylidene |
| CAS | 60907-88-2 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C10H13Cl/c1-7-5-4-6-10(8(7)2)9(3)11/h4-6,9H,1-3H3 |
1-(1-chlorethyl)-2,3-dimethylbenzylidene - Physico-chemical Properties
| Molecular Formula | C10H13Cl |
| Molar Mass | 168.66 |
| Density | 1.010 |
| Boling Point | 233°C |
| Flash Point | 93°C |
| Vapor Presure | 0.0887mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.514 |
1-(1-chlorethyl)-2,3-dimethylbenzylidene - Reference Information
| Use | 1-(1-chloroethyl)-2, 3-dimethylbenzene is an organic material, it is a key intermediate for the preparation of dexmedetomidine hydrochloride. |
| preparation | in a ML three-necked flask, add 0.5 ml of tetrahydrofuran (THF) and 12g of magnesium bar (mo1), heated to reflux, 2, 3-dimethylbromobenzene 92.5g(0.5 mo1) in THF solution was added dropwise, refluxed for 1H, cooled to room temperature, acetaldehyde 36ML (0.64mol)/THF100mL was added dropwise, reflux was continued for 1H, and THF was distilled off under reduced pressure. After cooling, an aqueous solution of NH4Cl (25g of NH4C1 80ml of water) and 300ml of ethyl acetate were slowly added. The layers were separated by standing, the organic phase was dried over anhydrous Na2S04, filtered, the solvent was evaporated, and then distilled under reduced pressure to collect a fraction of 115-118 °c/300Pa. Anhydrous zncl2200 G and concentrated HCl 300ml were added, and after sufficiently dissolving, 150g(1 mol) of the above fraction was added, followed by vigorous stirring for 4 hours. Layer, anhydrous CaC12 dry organic phase, filtered, filtrate distilled off solvent, vacuum distillation, collect 80~83 deg C/300Pa fraction to obtain product 1-(1-chloroethyl)-2, 3-dimethylbenzene (142g, yield 84.2%). |
Last Update：2024-04-09 21:11:58
Supplier List
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotation
CAS: 60907-88-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 60907-88-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotationCAS: 60907-88-2
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotationCAS: 60907-88-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 1-(1-Chloroethyl)-2,3-dimethylbenzene Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 1-(1-chloroethyl)-2,3-dimethylbenzene Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotation
CAS: 60907-88-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 60907-88-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotationCAS: 60907-88-2
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Request for quotationCAS: 60907-88-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 1-(1-Chloroethyl)-2,3-dimethylbenzene Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 1-(1-chloroethyl)-2,3-dimethylbenzene Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: 1-(2,3-Dimethylphenyl)ethyl chloride Visit Supplier Webpage Request for quotationCAS: 60907-88-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
1-(1-chlorethyl)-2,3-dimethylbenzylidene
2-(6-CHLORO-3-PYRIDINYL)-5,6-DIMETHYL-1H-1,3-BENZIMIDAZOLE
2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide
4,6-dichloro-5-(prop-2-yn-1-yl)pyrimidine
1820604-85-0
494221-10-2
352689-16-8
1,2-Bis[2-(1,3-dioxoisoindolin-2-yl)ethylthio]ethane
2680534-57-8
1,4-Dihydro-1-cyclopropyl-7-chloro-6-fluoro-4-oxo-5-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester
2-(6-CHLORO-3-PYRIDINYL)-5,6-DIMETHYL-1H-1,3-BENZIMIDAZOLE
2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxy-5-methylphenyl)acetamide
4,6-dichloro-5-(prop-2-yn-1-yl)pyrimidine
1820604-85-0
494221-10-2
352689-16-8
1,2-Bis[2-(1,3-dioxoisoindolin-2-yl)ethylthio]ethane
2680534-57-8
1,4-Dihydro-1-cyclopropyl-7-chloro-6-fluoro-4-oxo-5-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester