Name | 2'-C-Methyluridine |
Synonyms | EOS-61181 2'-C-Methyluridine Uridine, 2'-C-Methyl- 2'-C-Methyl-1-β-D-ribofuranosyluracil 1-(2-C-Methyl-β-D-ribofuranosyl)uracil 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)-3-METHYLFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione |
CAS | 31448-54-1 |
Molecular Formula | C10H14N2O6 |
Molar Mass | 258.23 |
Density | 1.572 |
Melting Point | 110-112 °C |
Appearance | powder to crystal |
Color | White to Almost white |
pKa | 9.39±0.10(Predicted) |
Storage Condition | 2-8°C |
background | nucleosides and their derivatives are effective in the treatment of malignant tumors and antiviral effects, of which 2 '-C-methyluridine is the synthesis of methylcytidine The key intermediate of drugs. Using D-ribose as the starting material, 1-O-acetyl -2,3,5-tri-O-benzoyl-β-D-baranyose was obtained by a series reaction of methylamine, benzoyl and acetylation. The optimal reaction conditions were determined by single-factor experiments in each step, and the yield reached 70.6%. Subsequently, the intermediate Danhongli, oxygen 1 methylation, and benzoylation reactions obtained the glycosyl part of 2 '-C-methyluridine. |
synthesis method | u6 and uricidine are coupled in the presence of silane reagents to form a uridine structure with a protective group, and then the protective group is removed to obtain the target product 22-C-methyluridine (u1), which is currently the most common route for the synthesis of nucleoside drugs. |