1-(3-Methoxyphenyl)piperazine
1-(3-Methoxyphenyl)piperazine
CAS: 16015-71-7
Molecular Formula: C11H16N2O
1-(3-Methoxyphenyl)piperazine - Names and Identifiers
| Name | 1-(3-Methoxyphenyl)piperazine |
| Synonyms | AKOS BBS-00003611 RARECHEM AH CK 0127 TIMTEC-BB SBB003619 Letermovir Intermediate 3 N-(3-Methoxyphenyl)piperazine 1-(3-METHOXYPHENYL)PIPERAZINE 1-(3-Methoxyphenyl)piperazine 1-(3-METHOXYLPHENYL) PIPERAZINE 1-(3-Methyoxyphenyl)-piperazine |
| CAS | 16015-71-7 |
| EINECS | 240-154-8 |
| InChI | InChI=1/C11H16N2O/c1-14-11-4-2-3-10(9-11)13-7-5-12-6-8-13/h2-4,9,12H,5-8H2,1H3 |
1-(3-Methoxyphenyl)piperazine - Physico-chemical Properties
| Molecular Formula | C11H16N2O |
| Molar Mass | 192.26 |
| Density | 1.114 g/mL at 25 °C (lit.) |
| Melting Point | 201-204°C |
| Boling Point | 150 °C/0.5 mmHg (lit.) |
| Flash Point | 195°F |
| Vapor Presure | 6.8E-05mmHg at 25°C |
| Appearance | Solid |
| Color | Colorless to Light yellow |
| pKa | 8.98±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | n20/D 1.5815(lit.) |
| MDL | MFCD00040733 |
1-(3-Methoxyphenyl)piperazine - Risk and Safety
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3267 8/PG 3 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | III |
1-(3-Methoxyphenyl)piperazine - Introduction
1-(3-Methoxyphenyl)piperazine, also known as 3-methoxyphenylpiperazine, is an organic compound. Its chemical formula is C11H14N2O, which contains a methoxy group and a piperazine ring. It is a white crystalline solid.
1-(3-Methoxyphenyl)piperazine has a wide range of applications in the field of medicine. It is an angiotensin antagonist used to treat high blood pressure and heart failure. It dilates blood vessels and lowers blood pressure by blocking the action of the vasoconstrictor angiotensin. In addition, it can also be used to treat heart disease, kidney disease and other related diseases.
The preparation method of 1-(3-Methoxyphenyl)piperazine can be obtained by the reaction of styrene, 3-methoxybenzaldehyde and piperazine. First, styrene and 3-methoxybenzaldehyde are reacted under appropriate conditions to produce methyl 3-methoxyphenylacrylate. This Ester is then subjected to a reductive conjugation reaction to give 1-(3-Methoxyphenyl)piperazine.
Regarding the safety information of this compound, it may have certain toxicity and irritation. In use should follow the correct method of operation, avoid contact with skin, eyes and mucous membranes. During storage and handling, attention should be paid to fire and explosion prevention measures, and avoid contact with oxidants and strong acids. Read the relevant safety technical instructions carefully before use and operate in accordance with appropriate protective measures. In case of accidental contact, rinse with water immediately and seek medical help.
1-(3-Methoxyphenyl)piperazine has a wide range of applications in the field of medicine. It is an angiotensin antagonist used to treat high blood pressure and heart failure. It dilates blood vessels and lowers blood pressure by blocking the action of the vasoconstrictor angiotensin. In addition, it can also be used to treat heart disease, kidney disease and other related diseases.
The preparation method of 1-(3-Methoxyphenyl)piperazine can be obtained by the reaction of styrene, 3-methoxybenzaldehyde and piperazine. First, styrene and 3-methoxybenzaldehyde are reacted under appropriate conditions to produce methyl 3-methoxyphenylacrylate. This Ester is then subjected to a reductive conjugation reaction to give 1-(3-Methoxyphenyl)piperazine.
Regarding the safety information of this compound, it may have certain toxicity and irritation. In use should follow the correct method of operation, avoid contact with skin, eyes and mucous membranes. During storage and handling, attention should be paid to fire and explosion prevention measures, and avoid contact with oxidants and strong acids. Read the relevant safety technical instructions carefully before use and operate in accordance with appropriate protective measures. In case of accidental contact, rinse with water immediately and seek medical help.
Last Update：2024-04-09 21:54:55
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View History
1-(3-Methoxyphenyl)piperazine
3-((二苯基亚甲基)氨基)-5-甲基噻吩-2-腈
carbamic acid [2-hydroxy-3-(2-methylphenoxy)propyl] ester
氯丁水乳粘合剂
4-甲基香豆素基-Α-D-吡喃半乳糖苷
C.I.12459
Spiro[1,3-dioxolane-2,2-[7]oxabicyclo[4.1.0]heptane] (8CI,9CI)
16,17-二癸氧基蒽酮紫(红外染料)
1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-phenyl-3-pyrrolidinecarboxylic acid
1-硝基-2-硝基丙烯
3-((二苯基亚甲基)氨基)-5-甲基噻吩-2-腈
carbamic acid [2-hydroxy-3-(2-methylphenoxy)propyl] ester
氯丁水乳粘合剂
4-甲基香豆素基-Α-D-吡喃半乳糖苷
C.I.12459
Spiro[1,3-dioxolane-2,2-[7]oxabicyclo[4.1.0]heptane] (8CI,9CI)
16,17-二癸氧基蒽酮紫(红外染料)
1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-phenyl-3-pyrrolidinecarboxylic acid
1-硝基-2-硝基丙烯