Molecular Formula | C46H43N9O13S2 |
Molar Mass | 994.01612 |
Melting Point | 83-84 °C |
Boling Point | 485.5±45.0 °C |
Specific Rotation(α) | (c, 0.171 in CHCl3)+37.5 |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | White crystalline powder |
Storage Condition | 2-8℃ |
effect | diacetyl big flower Inula lactone is a natural product, which can reverse the multidrug resistance of tumor cells, it can be used as a reversal agent of tumor multidrug resistance; Diacetyl large flower Inula lactone also has the effect of increasing the sensitivity of tumor multidrug resistant cells to antitumor drugs, and can be used as a chemosensitizer. |
preparation | the extraction method of sesquiterpene compounds including diacetyl big Inula lactone is as follows: take the dried heads of circumscribed flowers of traditional Chinese medicine and carry out the treatment according to the following steps: reflux extraction with ethanol of 6-10 times volume of the weight of the medicinal material, and concentrate under reduced pressure to obtain ethanol extract; Suspend the ethanol extract with water, extraction with petroleum ether, ethyl acetate, n-butanol, respectively, to obtain petroleum ether extract, ethyl acetate extract, n-butanol extract; The ethyl acetate extract, silica gel column chromatography, respectively, with petroleum ether-ethyl acetate, ethyl acetate, ethyl acetate-methanol gradient elution, TLC combining similar components, the resulting components were purified by preparative gel permeation chromatography GPC, gel (ToyopearlHW-40) column, semi-preparative HPLC to obtain sesquiterpene lactone compounds. |