1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide

1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide - Names and Identifiers

Name	7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide
Synonyms	lenvaim-C Lenvatinib Impurity 19 4-hydroxy-7-methoxyquinoline-6-carboxamide 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide 1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)- 6-Quinolinecarboxamide, 1,4-dihydro-7-methoxy-4-oxo-
CAS	417724-81-3

1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide - Physico-chemical Properties

Molecular Formula	C11H10N2O3
Molar Mass	218.21
Density	1.324±0.06 g/cm3(Predicted)
Boling Point	372.1±42.0 °C(Predicted)
pKa	15.36±0.20(Predicted)
Use	Uses 1, 4-dihydro-7-methoxy-4-oxo-6-quinolinformamide is a metabolite of lenvatinib, an oral multi-receptor tyrosine kinase inhibitor, including VEGF, FGF and SCF receptors.

1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide - Upstream Downstream Industry

Raw Materials

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxamide - Introduction

7-methoxy-4-ox-1 (7-Methoxy-4-oxo-1) is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or light yellow solid.
-Solubility: Soluble in most organic solvents, such as ethanol, chloroform and dichloromethane.
-Melting point: About 171-174 ° C.

Use:
-Chemical reagents: commonly used as intermediates in organic synthesis.
-Drug research: The compound has certain biological activity and can be used in the fields of drug development and efficacy evaluation.

Method:
1. From aniline:
-Aniline is reacted with acetic acid, acetic anhydride and hydrochloric acid to form acetanilide.
-Acetanilide reacts with 1,4-benzoquinone to produce 1,4-dihydro-7-acetylquinoline.
-Finally, 1,4-dihydro-7-acetylquinoline is oxidized and methylated to obtain 7-Methoxy-4-oxo-1.

Safety Information:
-The compound may cause certain harm to the human body, such as irritation to the eyes, skin and inhalation routes.
-During use, avoid direct contact with skin and eyes, and follow relevant safety procedures.
-During storage, the compound should be stored in a sealed container, away from heat and fire sources.

Please note that it is recommended to consult reliable chemical information for specific properties, uses, manufacturing methods and safety information of chemicals.

Last Update：2024-04-09 15:18:03