Name | 1,2-Dibromopropane |
Synonyms | 1.2-Dibromoethane 1,2-Dibromopropane 1,2-Dobromopropane 1,2-DIBROMOPROPANE 1,2-Dibromoproapne 11,2-DIBROMOPROPANE Propylene dibromide Propane,1,2-dibromo- (2S)-1,2-dibromopropane 1,2 - Propylene Dibromide |
CAS | 78-75-1 |
EINECS | 201-139-1 |
InChI | InChI=1/C3H6Br2/c1-3(5)2-4/h3H,2H2,1H3/t3-/m0/s1 |
Molecular Formula | C3H6Br2 |
Molar Mass | 201.89 |
Density | 1.937g/mLat 25°C(lit.) |
Melting Point | -55 °C |
Boling Point | 140-142°C(lit.) |
Flash Point | 35 °C |
Water Solubility | slightly soluble |
Solubility | organic solvents: miscible |
Vapor Presure | 7.68mmHg at 25°C |
Appearance | clear liquid |
Color | Colorless to Light yellow to Light orange |
Merck | 14,7853 |
BRN | 1718884 |
Storage Condition | Flammables area |
Stability | Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, magnesium. |
Refractive Index | n20/D 1.519(lit.) |
Physical and Chemical Properties | Character non-combustible non-explosive liquid. melting point -55 ℃ boiling point 140~142 ℃ relative density 1.933g/cm3 refractive index 1.5192 |
Use | Used in organic synthesis and also as a solvent |
Hazard Symbols | Xn - Harmful |
Risk Codes | R10 - Flammable R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing. |
UN IDs | UN 1993 3/PG 3 |
WGK Germany | 3 |
RTECS | TX8574000 |
TSCA | Yes |
HS Code | 29033036 |
Hazard Class | 3 |
Packing Group | III |
This product is non-combustible liquid. Melting Point -58 °c. Boiling point 139.6 °c. Density 1.933g/cm3. The refractive index (n ~ o) is 1. 5192, the solubility in water is 0.2% at 25 ℃ and 0.3% at 80 ℃, which can decompose and release toxic gas at high temperature.
1. Direct reaction of propylene with bromine.
2. After mixing the bromopropane with the iron powder, heat to 40~50 °c. Slowly add bromine Dropwise, reflux for 2 hours, after completion of the reaction, wash with water, remove iron residue, wash with sodium carbonate solution to neutral, then dry, fractionate, collect 140~144 ℃ fraction, that's right.
3. Bromination of propanol.
used as a raw material, chemical reagent and solvent for organic synthesis.
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | use as an intermediate in organic synthesis use as a raw material, chemical reagent and solvent in organic synthesis. used in organic synthesis, also used as solvent |
production method | 1.1, 2-dibromopropane is available from the direct bromination of propylene. 2. The bromopropane is brominated by first mixing the bromopropane with iron powder, heating to 40-50 ℃, slowly adding bromine, and refluxing for 2H after adding. Then, the iron residue was filtered off, and the filtrate was washed with water several times, 5% sodium carbonate solution once, and then 5% sodium thiosulfate solution to remove free bromine. Dry with anhydrous calcium chloride. Fractionation was carried out, and the 139-142 °c fraction was collected as the finished product. 3. Bromination of propanol. |
category | toxic substances |
toxicity grade | poisoning |
Acute toxicity | oral-rat LD50: 741 mg/kg; Oral-mouse LD50: 676 mg/kg |
flammability hazard characteristics | flammable, spicy and irritating smoke containing bromide emitted from fire |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Separate from food, oxidant and acid |
fire extinguishing agent | foam, dry powder, 1211 fire extinguishing agent |
Occupational Standard | SEL 5 mg/m3 |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |