Name | Elcatonin |
Synonyms | HC-58 Elcatonin ELCATONIN Elcatonine Elcatonina Elcatoninum 29-l-alanine- ELCATONIN (EEL) Carbocalcitonin Elcatoninum [INN-Latin] Elcatonine [INN-French] Elcatonina [INN-Spanish] (aminosubericacid1,7)-eelcalcitonin (Aminosuberic acid 1,7)-eel calcitonin (L-ALPHA-AMINOSUBERIC ACID1,7)-CALCITONIN (EEL) (DES CYS1,CYCLO (SER2-ASU7))-CALCITONIN (EEL) ACETATE SALT 1-butanoicacid-26-l-asparticacid-27-l-valine-7-dicarbacalcitonin(salmon) 1,7-Dicarbacalcitonin, 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine- 1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine- 1-Butyric acid-7-(L-2-aminobutyric acid)-26-L-aspartic acid-27-L-valine-29-L-alaninecalcitonin (salmon) CYCLO(-SER-ASN-LEU-SER-THR-ASU)-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASP-VAL-GLY-ALA-GLY-THR-PRO-NH2 |
CAS | 60731-46-6 |
EINECS | 262-393-7 |
InChI | InChI=1/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128(217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77(16)193)143(232)171-87)123(212)161-63-109(202)165-85(31-23-25-47-149)124(213)173-95(55-72(7)8)133(222)181-101(65-191)138(227)169-89(41-44-105(152)198)126(215)167-91(43-46-111(204)205)127(216)175-94(54-71(5)6)132(221)177-97(58-82-61-158-68-163-82)135(224)166-86(32-24-26-48-150)125(214)174-93(53-70(3)4)131(220)168-90(42-45-106(153)199)130(219)187-118(79(18)195)145(234)180-100(57-81-37-39-83(197)40-38-81)146(235)190-51-29-35-104(190)140(229)170-88(33-27-49-159-148(156)157)129(218)186-117(78(17)194)144(233)179-99(60-112(206)207)137(226)184-114(74(11)12)141(230)162-62-108(201)164-76(15)121(210)160-64-110(203)183-119(80(19)196)147(236)189-50-28-34-103(189)120(155)209/h37-40,61,68-80,84-104,114-119,191-197H,20-36,41-60,62-67,149-151H2,1-19H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,209)(H,158,163)(H,160,210)(H,161,212)(H,162,230)(H,164,201)(H,165,202)(H,166,224)(H,167,215)(H,168,220)(H,169,227)(H,170,229)(H,171,232)(H,172,211)(H,173,213)(H,174,214)(H,175,216)(H,176,225)(H,177,221)(H,178,231)(H,179,233)(H,180,234)(H,181,222)(H,182,223)(H,183,203)(H,184,226)(H,185,217)(H,186,218)(H,187,219)(H,188,228)(H,204,205)(H,206,207)(H4,156,157,159)/t76-,77+,78+,79+,80+,84-,85-,86-,87?,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,114-,115-,116?,117-,118-,119-/m0/s1 |
Molecular Formula | C148H244N42O47 |
Molar Mass | 3363.83 |
Density | 1.49±0.1 g/cm3(Predicted) |
Storage Condition | -15°C |
Refractive Index | 1.658 |
Use | Used as an electrolyte supplement |
RTECS | HS9270000 |
overview | ecalcitonin (lecatonin), also known as yitonin, is a new type of artificially synthesized calcitonin drug. It has the effects of lowering blood calcium and blood phosphorus, as well as the bone resorption promotion effect of inhibiting prostaglandin E1, 1,25-(OH)2 vitamin D2 and osteoclast activating factor, it can also inhibit the secretion of gastric juice and gastric acid, promote the excretion of Na and K from the urine, increase urine output, and increase the Na /K ratio; clinically commonly used in deforming osteitis (Paget's disease), osteoporosis, Hypercalcemia, painful bone disease; also used for renal osteodystrophy and malignant tumor bone metastasis. |
pharmacological action | this product can significantly reduce serum calcium, with the same effect as salmon calcitonin, and continuous medication does not produce drug resistance. This product has the effect of reducing blood calcium and blood phosphorus, as well as inhibiting the bone absorption of parathyroid extract, prostaglandin E1, 1,25-(OH)2 vitamin D2, and osteoclast activation factor; it can also inhibit gastric juice and gastric acid secretion, promote the excretion of Na and K from the urine, increase the urine output, and increase the Na/K ratio. The blood concentration of healthy adults reached the peak after intramuscular injection, rapid intravenous injection or intravenous drip at 30, 5 and 10 minutes respectively, and the duration was 120, 45 and 40 minutes respectively. It can be distributed in kidney, intestine, stomach, liver, bone and other tissues. The liver and kidney are inactivated by enzymes in microsomes, and about 74% and 7% are excreted from urine and feces respectively. |
clinical application | for deforming osteitis (Paget's disease), osteoporosis, hypercalcemia, painful bone disease. It is also used for renal osteodystrophy and malignant tumor bone metastasis. |
adverse reactions | allergic reactions such as rash and urticaria may occur, and occasionally shock may occur. Sometimes nausea, vomiting, diarrhea, loss of appetite, heartburn, flushing, heat sensation, chest pressure, palpitations, headache, dizziness, gait instability, serum aminotransferase rise, hyponatremia, edema, itching, chills, malaise. Occasionally have asthma attacks, sweating, numbness of fingers, frequent urination, blurred vision, tetany, tinnitus, abdominal pain and thirst. |
precautions | (1) this product can reduce adverse reactions by using anti-vomiting drugs before going to bed or taking drugs before taking drugs. (2) This product is a polypeptide preparation, which may cause shock. Therefore, it should be used with caution for patients who are prone to allergic reactions such as rash, erythema, urticaria, bronchial asthma or patients with past history. (3) Use with caution in patients with abnormal liver function. (4) When intramuscular injection, pay attention to avoid the nerve to the site and blood vessels. If there is severe pain or blood withdrawal, the needle should be quickly removed and transposed for injection. During repeated injections, the injection site should be changed. (5) This product should not be used for a long time. (6) Glass and plastic will adsorb the drug and reduce its efficacy. It should be used as soon as possible after preparation. (2015-12-02) |
use | electrolyte supplement. |